Krång Anna-Sara, Dahlström Mia
Department of Marine Ecology, Göteborg University, Kristineberg Marine Research Station, S-450 34 Fiskebäckskil, Sweden.
Mar Pollut Bull. 2006 Dec;52(12):1776-83. doi: 10.1016/j.marpolbul.2006.09.015. Epub 2006 Oct 27.
Environmental hazards associated with traditional, toxic antifouling coatings based on heavy metals calls for the development of alternative, environmentally acceptable antifouling compounds. Medetomidine ((+/-)-4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole) is a candidate antifouling biocide which impedes settlement of barnacles in the nanomolar range. Prior to introducing novel biocides it is of great importance to consider potential effects on non-target organisms. This study is the first to investigate the effects of medetomidine on the amphipod Corophium volutator, specifically effects on male mate search behaviour. In a laboratory, Y-maze bioassay, C. volutator males were allowed to follow female pheromones after 24 h exposure to 0 (control), 0.01 and 0.1 microg mL(-1) medetomidine. We found that exposure to medetomidine at both concentrations significantly reduced pheromone induced mate search (by 42-71%), with fewer males crawling towards female odour. The results obtained indicate that medetomidine may impair the reproductive fitness of non-target crustaceans, an aspect that needs to be considered before further commercialisation.
与基于重金属的传统有毒防污涂料相关的环境危害促使人们开发替代的、环境可接受的防污化合物。美托咪定（(+/-)-4-[1-(2,3-二甲基苯基)乙基]-1H-咪唑）是一种候选防污杀菌剂，它在纳摩尔范围内可阻止藤壶附着。在引入新型杀菌剂之前，考虑其对非目标生物的潜在影响非常重要。本研究首次调查了美托咪定对双壳纲动物卷贝的影响，特别是对雄性寻找配偶行为的影响。在实验室的Y型迷宫生物测定中，将卷贝雄性暴露于0（对照）、0.01和0.1微克/毫升美托咪定24小时后，让它们追踪雌性信息素。我们发现，暴露于这两种浓度的美托咪定均显著降低了信息素诱导的寻找配偶行为（降低了42%-71%），向雌性气味爬行的雄性减少。所得结果表明，美托咪定可能会损害非目标甲壳类动物的繁殖适应性，这是在进一步商业化之前需要考虑的一个方面。
