Lagziel-Simis Shira, Cohen-Hadar Noa, Moscovich-Dagan Hila, Wine Yariv, Freeman Amihay
Department of Molecular Microbiology and Biotechnology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Curr Opin Biotechnol. 2006 Dec;17(6):569-73. doi: 10.1016/j.copbio.2006.10.005. Epub 2006 Oct 30.
Biomimetics--the concept of taking ideas from nature and implementing them in technology--has found particular use for the development of nanoscale materials. One such approach employs protein-mediated biotemplating for the nanostructuring of inorganic material. Recently, two key advances have been witnessed in this field. Firstly, the number of successfully employed biotemplates, including feasibility demonstrations of using three-dimensional crystalline structures, has been expanded. Secondly, the introduction of site-directed mutations on the protein template, or the display of peptides that exhibit effective biorecognition sequences for inorganic structures, has led to substantial improvements in our ability to control protein-mediated biotemplating. Taken together, these achievements will pave the way for the successful application of protein-mediated biotemplating in the future.
仿生学——从自然中获取灵感并将其应用于技术的理念——在纳米级材料的开发中得到了特别应用。一种这样的方法是利用蛋白质介导的生物模板法对无机材料进行纳米结构化。最近，该领域取得了两项关键进展。首先，成功应用的生物模板数量有所增加，包括使用三维晶体结构的可行性证明。其次，在蛋白质模板上引入定点突变，或展示对无机结构具有有效生物识别序列的肽，极大地提高了我们控制蛋白质介导的生物模板法的能力。综上所述，这些成果将为蛋白质介导的生物模板法在未来的成功应用铺平道路。
