1型葡萄糖转运蛋白的表达与涎腺肿瘤患者的不良预后相关。
Glucose transporter type 1 expression are associated with poor prognosis in patients with salivary gland tumors.
作者信息
Mori Yusuke, Tsukinoki Keiichi, Yasuda Masanori, Miyazawa Masaki, Kaneko Akihiro, Watanabe Yoshihisa
机构信息
Department of Maxillofacial Diagnostic Science, Division of Pathology, Kanagawa Dental College, 82 Inaokacyo, Yokosuka, Kanagawa 238-8580, Japan.
出版信息
Oral Oncol. 2007 Jul;43(6):563-9. doi: 10.1016/j.oraloncology.2006.06.006. Epub 2006 Oct 27.
The objective of this study was to investigate the expression of Glucose transporter type 1 (GLUT1) and its relation to clinicopathologic parameters in patients with salivary gland tumors. Tissue samples were 49 cases of malignant tumors, 38 cases of benign tumors, mainly pleomorphic adenoma and 10 cases of normal salivary glands. Immunohistochemically, GLUT1 Labeling Index of malignant tumor was significantly higher than benign tumor. In RT-PCR assay, GLUT1 mRNA level in malignant tumor were higher than that of normal tissue. In malignant tumors, expression of GLUT1 correlated significantly with tumor size (p=0.002) and distant metastasis (p=0.007). Cumulative survival rate of high expression group was significantly lower than that of low (p<0.001). In multivariable analysis, overall survival significantly correlated with lymph node metastasis (p=0.042) and GLUT1 expression (p=0.022). These results suggest that GLUT1 expression may provide useful prognostic information in patients with salivary gland carcinoma.
本研究的目的是调查1型葡萄糖转运蛋白（GLUT1）在涎腺肿瘤患者中的表达及其与临床病理参数的关系。组织样本包括49例恶性肿瘤、38例良性肿瘤（主要为多形性腺瘤）和10例正常涎腺组织。免疫组化结果显示，恶性肿瘤的GLUT1标记指数显著高于良性肿瘤。逆转录聚合酶链反应（RT-PCR）检测结果显示，恶性肿瘤中GLUT1 mRNA水平高于正常组织。在恶性肿瘤中，GLUT1的表达与肿瘤大小（p=0.002）和远处转移（p=0.007）显著相关。高表达组的累积生存率显著低于低表达组（p<0.001）。多变量分析结果显示，总生存率与淋巴结转移（p=0.042）和GLUT1表达（p=0.022）显著相关。这些结果表明，GLUT1表达可能为涎腺癌患者提供有用的预后信息。
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