Cowgill Sarah M, Al-Saadi Sam, Villadolid Desiree, Zervos Emmanuel E, Rosemurgy Alexander S
Digestive Disorders Center, Tampa General Hospital and the Department of Surgery, University of South Florida College of Medicine, PO Box 1289, Room F145, Tampa, FL 33601, USA.
Am J Surg. 2006 Nov;192(5):622-6. doi: 10.1016/j.amjsurg.2006.08.010.
BACKGROUND: This study was undertaken to compare patients with gastroesophageal reflux disease (GERD) with or without Barrett's esophagus for severity and frequency of symptoms and their response to antireflux surgery. METHODS: Eighty patients with GERD and Barrett's esophagus and 93 concurrent patients with GERD alone, all of whom underwent laparoscopic Nissen fundoplication, were compared by using symptom scores graded by a Likert scale. RESULTS: Before fundoplication, patients with Barrett's esophagus had higher DeMeester scores. Symptom scores were not different for patients with versus without Barrett's esophagus before or after laparoscopic Nissen fundoplication. CONCLUSIONS: Before and after fundoplication, patients with Barrett's esophagus, despite more severe reflux, have symptoms nearly identical in frequency and severity when compared with patients with GERD alone. Regardless of presence of Barrett's, all improve dramatically with laparoscopic Nissen fundoplication. Barrett's esophagus does not impact presentation before or outcome after laparoscopic Nissen fundoplication.
背景：本研究旨在比较患有或未患有巴雷特食管的胃食管反流病（GERD）患者的症状严重程度和频率，以及他们对抗反流手术的反应。 方法：80例患有GERD和巴雷特食管的患者以及93例同时患有GERD的患者，所有患者均接受了腹腔镜尼森胃底折叠术，通过使用李克特量表分级的症状评分进行比较。 结果：在进行胃底折叠术之前，患有巴雷特食管的患者的DeMeester评分更高。在腹腔镜尼森胃底折叠术之前或之后，患有与未患有巴雷特食管的患者的症状评分没有差异。 结论：在进行胃底折叠术之前和之后，尽管患有巴雷特食管的患者反流更严重，但与仅患有GERD的患者相比，其症状在频率和严重程度上几乎相同。无论是否存在巴雷特食管，所有患者在接受腹腔镜尼森胃底折叠术后都有显著改善。巴雷特食管不影响腹腔镜尼森胃底折叠术之前的表现或术后结果。
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