Mazzarelli Joan M, Brestelli John, Gorski Regina K, Liu Junmin, Manduchi Elisabetta, Pinney Deborah F, Schug Jonathan, White Peter, Kaestner Klaus H, Stoeckert Christian J
Department of Genetics, School of Medicine, Center for Bioinformatics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Nucleic Acids Res. 2007 Jan;35(Database issue):D751-5. doi: 10.1093/nar/gkl748. Epub 2006 Oct 27.
EPConDB (http://www.cbil.upenn.edu/EPConDB) is a public web site that supports research in diabetes, pancreatic development and beta-cell function by providing information about genes expressed in cells of the pancreas. EPConDB displays expression profiles for individual genes and information about transcripts, promoter elements and transcription factor binding sites. Gene expression results are obtained from studies examining tissue expression, pancreatic development and growth, differentiation of insulin-producing cells, islet or beta-cell injury, and genetic models of impaired beta-cell function. The expression datasets are derived using different microarray platforms, including the BCBC PancChips and Affymetrix gene expression arrays. Other datasets include semi-quantitative RT-PCR and MPSS expression studies. For selected microarray studies, lists of differentially expressed genes, derived from PaGE analysis, are displayed on the site. EPConDB provides database queries and tools to examine the relationship between a gene, its transcriptional regulation, protein function and expression in pancreatic tissues.
EPConDB（http://www.cbil.upenn.edu/EPConDB）是一个公共网站，通过提供胰腺细胞中表达基因的信息来支持糖尿病、胰腺发育和β细胞功能方面的研究。EPConDB展示单个基因的表达谱以及有关转录本、启动子元件和转录因子结合位点的信息。基因表达结果来自于对组织表达、胰腺发育与生长、胰岛素产生细胞的分化、胰岛或β细胞损伤以及β细胞功能受损的遗传模型的研究。表达数据集是使用不同的微阵列平台获得的，包括BCBC PancChips和Affymetrix基因表达阵列。其他数据集包括半定量RT-PCR和MPSS表达研究。对于选定的微阵列研究，来自PaGE分析的差异表达基因列表会在该网站上展示。EPConDB提供数据库查询和工具，以研究基因、其转录调控、蛋白质功能与胰腺组织中表达之间的关系。
Zotero 插件