对人类胎儿和成人器官中DNA结合转录因子基因表达的全面调查。
A comprehensive survey of DNA-binding transcription factor gene expression in human fetal and adult organs.
作者信息
Kong Y Megan, Macdonald Raymond J, Wen Xiaofei, Yang Peng, Barbera Victor M, Swift Galvin H
机构信息
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, 75390, USA.
出版信息
Gene Expr Patterns. 2006 Oct;6(7):678-86. doi: 10.1016/j.modgep.2006.01.002. Epub 2006 Feb 17.
A global survey of RNA from 14 fetal and 12 adult human organs by RT-PCR determined the expression patterns of 790 genes encoding DNA-binding transcription factors. The data can be sorted to identify sets of transcription factors with expression relatively restricted to a given organ or to particular organ groups. These data are a resource to help define the spectrum of transcription factor control, contribute to the elucidation of transcription factor cascades responsible for the development and maintenance of each organ, and provide a baseline to study the effects of disease or developmental defects.
通过逆转录聚合酶链反应（RT-PCR）对来自14个胎儿和12个成人人体器官的RNA进行的全球调查，确定了790个编码DNA结合转录因子的基因的表达模式。这些数据可以进行分类，以识别那些表达相对局限于特定器官或特定器官组的转录因子集合。这些数据有助于确定转录因子控制的范围，有助于阐明负责每个器官发育和维持的转录因子级联反应，并为研究疾病或发育缺陷的影响提供一个基线。
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