Hulbert Erin M, Smink Luc J, Adlem Ellen C, Allen James E, Burdick David B, Burren Oliver S, Cassen Victor M, Cavnor Christopher C, Dolman Geoffrey E, Flamez Daisy, Friery Karen F, Healy Barry C, Killcoyne Sarah A, Kutlu Burak, Schuilenburg Helen, Walker Neil M, Mychaleckyj Josyf, Eizirik Decio L, Wicker Linda S, Todd John A, Goodman Nathan
Institute for Systems Biology, Seattle, WA, USA.
Nucleic Acids Res. 2007 Jan;35(Database issue):D742-6. doi: 10.1093/nar/gkl933. Epub 2006 Dec 14.
T1DBase (http://T1DBase.org) [Smink et al. (2005) Nucleic Acids Res., 33, D544-D549; Burren et al. (2004) Hum. Genomics, 1, 98-109] is a public website and database that supports the type 1 diabetes (T1D) research community. T1DBase provides a consolidated T1D-oriented view of the complex data world that now confronts medical researchers and enables scientists to navigate from information they know to information that is new to them. Overview pages for genes and markers summarize information for these elements. The Gene Dossier summarizes information for a list of genes. GBrowse [Stein et al. (2002) Genome Res., 10, 1599-1610] displays genes and other features in their genomic context, and Cytoscape [Shannon et al. (2003) Genome Res., 13, 2498-2504] shows genes in the context of interacting proteins and genes. The Beta Cell Gene Atlas shows gene expression in beta cells, islets, and related cell types and lines, and the Tissue Expression Viewer shows expression across other tissues. The Microarray Viewer shows expression from more than 20 array experiments. The Beta Cell Gene Expression Bank contains manually curated gene and pathway annotations for genes expressed in beta cells. T1DMart is a query tool for markers and genotypes. PosterPages are 'home pages' about specific topics or datasets. The key challenge, now and in the future, is to provide powerful informatics capabilities to T1D scientists in a form they can use to enhance their research.
T1DBase（http://T1DBase.org）[斯明克等人（2005年），《核酸研究》，第33卷，D544 - D549页；布伦等人（2004年），《人类基因组学》，第1卷，98 - 109页]是一个支持1型糖尿病（T1D）研究群体的公共网站和数据库。T1DBase提供了一个面向T1D的综合视角，呈现了医学研究人员目前所面对的复杂数据世界，使科学家能够从他们已知的信息导航到对他们来说新的信息。基因和标记的概述页面总结了这些元素的信息。基因档案总结了一系列基因的信息。GBrowse[斯坦因等人（2002年），《基因组研究》，第10卷，1599 - 1610页]在基因组背景下展示基因和其他特征，而Cytoscape[香农等人（2003年），《基因组研究》，第13卷，2498 - 2504页]在相互作用的蛋白质和基因背景下展示基因。β细胞基因图谱展示了β细胞、胰岛及相关细胞类型和细胞系中的基因表达，组织表达查看器展示了其他组织中的表达情况。微阵列查看器展示了来自20多个阵列实验的表达情况。β细胞基因表达库包含了对β细胞中表达的基因进行人工整理的基因和通路注释。T1DMart是一个用于标记和基因型的查询工具。海报页面是关于特定主题或数据集的“主页”。当前以及未来的关键挑战在于，以一种T1D科学家能够用于加强其研究的形式，为他们提供强大的信息学能力。
