La Marca A, Giulini S, Tirelli A, Bertucci E, Marsella T, Xella S, Volpe A
Mother-Infant Department, Institute of Obstetrics and Gynecology, University of Modena and Reggio Emilia, Modena, Italy.
Hum Reprod. 2007 Mar;22(3):766-71. doi: 10.1093/humrep/del421. Epub 2006 Oct 27.
Recently, a new marker, the anti-Müllerian hormone (AMH), has been evaluated as a marker of ovarian response. Serum AMH levels have been measured at frequent time-points during the menstrual cycle, suggesting the complete absence of fluctuation. The aim of this study was to evaluate whether serum AMH measurement on any day of the menstrual cycle could predict ovarian response in women undergoing assisted reproductive technology (ART).
This study included 48 women attending the IVF/ICSI programme. Blood withdrawal for AMH measurement was performed in all the patients independently of the day of the menstrual cycle.
Women in the lowest AMH quartile (<0.4 ng/ml) were older and required a higher dose of recombinant FSH than women in the highest quartile (>7 ng/ml). All the cancelled cycles due to absent response were in the group of the lowest AMH quartile, whereas the cancelled cycles due to risk of ovarian hyperstimulation syndrome (OHSS) were in the group of the highest AMH quartile. This study demonstrated a strong correlation between serum AMH levels and ovarian response to gonadotrophin stimulation.
For the first time, clinicians may have a reliable serum marker of ovarian response that can be measured independently of the day of the menstrual cycle.
最近，一种新的标志物——抗苗勒管激素（AMH），已被评估为卵巢反应的标志物。在月经周期的多个时间点测量血清AMH水平，结果显示其完全没有波动。本研究的目的是评估在月经周期的任何一天测量血清AMH是否能够预测接受辅助生殖技术（ART）的女性的卵巢反应。
本研究纳入了48名参加体外受精/卵胞浆内单精子注射（IVF/ICSI）项目的女性。所有患者均在月经周期的任意一天进行采血以测量AMH。
AMH处于最低四分位数（<0.4 ng/ml）的女性年龄更大，与处于最高四分位数（>7 ng/ml）的女性相比，她们需要更高剂量的重组促卵泡激素（FSH）。所有因无反应而取消的周期均在AMH最低四分位数组中，而因卵巢过度刺激综合征（OHSS）风险而取消的周期则在AMH最高四分位数组中。本研究表明血清AMH水平与卵巢对促性腺激素刺激的反应之间存在密切相关性。
临床医生首次可能拥有一种可靠的卵巢反应血清标志物，该标志物可在月经周期的任意一天进行测量。
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