Madikyzy Malika, Durmanova Aigul, Trofimov Alexander, Akbay Burkitkan, Tokay Tursonjan
Department of Internal Medicine, University Medical Center, 46 Syganak St., Astana 010000, Kazakhstan.
Department of Biology, School of Sciences and Humanities, Nazarbayev University, 53 Kabanbay Batyr Ave., Astana 010000, Kazakhstan.
Biomedicines. 2024 Oct 14;12(10):2333. doi: 10.3390/biomedicines12102333.
Polycystic Ovarian Syndrome (PCOS) is a common endocrine condition that affects 8-13% of women of reproductive age. In Kazakhstan, the prevalence of this syndrome is particularly high compared with other countries and the global average. Currently, the diagnosis of PCOS is based on internationally established Rotterdam criteria, using hyperandrogenism as a key parameter. These criteria are applied to diagnose PCOS in all female patients, although obese patients may have excess testosterone produced by adipose tissue. To avoid possible misdiagnosis, an additional criterion, especially for the diagnosis of PCOS in obese women, could be considered. The of this study was to identify whether anti-Müllerian hormone (AMH) or other biochemical criteria can be used for this purpose. A total of 138 women were recruited for this study and grouped into control (n = 46), obese subjects without PCOS (n = 67), and obese patients with PCOS (n = 25). The health status, anthropometric parameters, and serum indicators for glucose, glycosylated hemoglobin, and hormone levels were examined for all subjects. Statistical data were analyzed using GraphPad Prism 10 software for interpretation of the data. Serum AMH, testosterone, and LH were positively correlated in obese PCOS patients, while AMH and FSH were negatively correlated. Compared with other biochemical indicators, the serum AMH and testosterone levels in obese PCOS patients were significantly higher than those in non-PCOS patients (regardless of obesity), and AMH was also positively correlated with testosterone. AMH appears to be a reliable criterion in addition to testosterone for the diagnosis of PCOS in obese women.
多囊卵巢综合征（PCOS）是一种常见的内分泌疾病，影响8%至13%的育龄女性。在哈萨克斯坦，与其他国家和全球平均水平相比，这种综合征的患病率特别高。目前，PCOS的诊断基于国际公认的鹿特丹标准，将高雄激素血症作为关键参数。这些标准适用于所有女性患者以诊断PCOS，尽管肥胖患者可能因脂肪组织产生过多睾酮。为避免可能的误诊，可以考虑增加一项标准，特别是用于诊断肥胖女性的PCOS。本研究的目的是确定抗苗勒管激素（AMH）或其他生化标准是否可用于此目的。本研究共招募了138名女性，分为对照组（n = 46）、无PCOS的肥胖受试者（n = 67）和患有PCOS的肥胖患者（n = 25）。对所有受试者检查了健康状况、人体测量参数以及血糖、糖化血红蛋白和激素水平的血清指标。使用GraphPad Prism 10软件分析统计数据以解释数据。肥胖PCOS患者的血清AMH、睾酮和促黄体生成素（LH）呈正相关，而AMH和促卵泡生成素（FSH）呈负相关。与其他生化指标相比，肥胖PCOS患者的血清AMH和睾酮水平显著高于非PCOS患者（无论是否肥胖），且AMH与睾酮也呈正相关。除睾酮外，AMH似乎是诊断肥胖女性PCOS的可靠标准。
