Tsepelidis S, Devreker F, Demeestere I, Flahaut A, Gervy Ch, Englert Y
Department of Obstetrics and Gynaecology, Université Libre de Bruxelles, Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium.
Hum Reprod. 2007 Jul;22(7):1837-40. doi: 10.1093/humrep/dem101. Epub 2007 May 7.
Anti-Müllerian hormone (AMH), secreted by the granulosa cells of preantral and small antral follicles, has been described as a potential marker of the ovarian reserve. The aim of this prospective study is to investigate the variations of AMH during the menstrual cycle in a young selected population of normo-ovulatory women and to analyse the correlation with other cyclic hormones.
Twenty healthy volunteers from 19 to 35 years old, with regular menstrual cycles (26-31 days), normal ovulation (day 10-16), normal hormonal profile and normal body mass index (18-26 kg/m2) were recruited. AMH, inhibin B, LH, FSH, estradiol and progesterone were measured on days 3, 7, 10, 11, 12, 13, 14, 15, 16, 18, 21 and 25 of a spontaneous cycle.
AMH serum levels, either expressed by cycle day or aligned according to the ovulation day, did not show any significant variations during the menstrual cycle.
No significant fluctuation of the AMH level during the menstrual cycle was observed. Therefore, this hormone is particularly interesting for clinical evaluation of the ovarian reserve as it may be used at any time during the cycle.
抗苗勒管激素（AMH）由窦前卵泡和小窦卵泡的颗粒细胞分泌，已被描述为卵巢储备的潜在标志物。这项前瞻性研究的目的是调查正常排卵的年轻女性特定人群在月经周期中AMH的变化，并分析其与其他周期性激素的相关性。
招募了20名年龄在19至35岁之间的健康志愿者，她们月经周期规律（26 - 31天），排卵正常（第10 - 16天），激素水平正常，体重指数正常（18 - 26 kg/m²）。在自然周期的第3、7、10、11、12、13、14、15、16、18、21和25天测量AMH、抑制素B、促黄体生成素（LH）、促卵泡生成素（FSH）、雌二醇和孕酮。
无论是按月经周期日表示还是根据排卵日排列，AMH血清水平在月经周期中均未显示出任何显著变化。
在月经周期中未观察到AMH水平有显著波动。因此，这种激素对于卵巢储备的临床评估特别有意义，因为它可以在周期的任何时间使用。
