Liu George E, Adams Mark D
Bovine Functional Genomics Laboratory, Animal and Natural Resources Institute, US Department of Agriculture-Agriculture Research Service, Beltsville, MD, USA.
Methods Mol Med. 2006;128:101-23. doi: 10.1007/978-1-59745-159-8_8.
Disorders of the cardiovascular system are often caused by the interaction of genetic and environmental factors that jointly contribute to individual susceptibility. Genomic data and bioinformatics tools generated from genome projects, coupled with functional verification, offer novel approaches to study both rare single-gene and complex multigenic cardiovascular diseases. These approaches include gene mapping using genome variation, especially single-nucleotide polymorphisms and comparative genomics within and between species. This chapter illustrates the major genome resources, associated bioinformatics tools, and their potential application in cardiovascular research.
心血管系统疾病通常由遗传因素和环境因素相互作用引起，这些因素共同导致个体易感性。基因组计划产生的基因组数据和生物信息学工具，结合功能验证，为研究罕见单基因和复杂多基因心血管疾病提供了新方法。这些方法包括利用基因组变异进行基因定位，尤其是单核苷酸多态性以及物种内部和物种之间的比较基因组学。本章阐述了主要的基因组资源、相关生物信息学工具及其在心血管研究中的潜在应用。
