Reue Karen, Vergnes Laurent
Department of Human Genetics and Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
J Lipid Res. 2006 Sep;47(9):1891-907. doi: 10.1194/jlr.R600020-JLR200. Epub 2006 Jul 11.
The availability of genomic resources has already had a tremendous impact on biomedical research. In this review, we describe how whole genome sequence and high-throughput functional genomics projects have facilitated the identification and characterization of important genes in lipid metabolism and disease. We review key approaches and lipid genes identified in the first years of this century and discuss how genomic resources are likely to streamline gene identification and functional characterization in the future.
基因组资源的可用性已经对生物医学研究产生了巨大影响。在本综述中，我们描述了全基因组序列和高通量功能基因组学项目如何促进了脂质代谢和疾病中重要基因的鉴定和表征。我们回顾了本世纪头几年确定的关键方法和脂质基因，并讨论了基因组资源在未来可能如何简化基因鉴定和功能表征。
