Sasano Tetsuo, McDonald Amy D, Kikuchi Kan, Donahue J Kevin
Heart and Vascular Research Center, MetroHealth Hospital, Case Western Reserve University School of Medicine, Rammelkamp 653, 2500 MetroHealth Drive, Cleveland, Ohio 44109, USA.
Nat Med. 2006 Nov;12(11):1256-8. doi: 10.1038/nm1503. Epub 2006 Oct 29.
Ventricular tachycardia is a common and lethal complication after myocardial infarction. Here we show that focal transfer of a gene encoding a dominant-negative version of the KCNH2 potassium channel (KCNH2-G628S) to the infarct scar border eliminated all ventricular arrhythmias in a porcine model. No proarrhythmia or other negative effects were discernable. Our results demonstrate the potential viability of gene therapy for ablation of ventricular arrhythmias.
室性心动过速是心肌梗死后常见的致死性并发症。在此我们表明,将编码KCNH2钾通道显性负性版本(KCNH2-G628S)的基因局部转移至梗死瘢痕边缘,可消除猪模型中的所有室性心律失常。未发现促心律失常或其他负面影响。我们的结果证明了基因治疗消除室性心律失常的潜在可行性。