Gerondakis S, Grumont R, Gugasyan R, Wong L, Isomura I, Ho W, Banerjee A
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Oncogene. 2006 Oct 30;25(51):6781-99. doi: 10.1038/sj.onc.1209944.
The nuclear factor-kappaB (NF-kappaB) signalling pathway serves a crucial role in regulating the transcriptional responses of physiological processes that include cell division, cell survival, differentiation, immunity and inflammation. Here we outline studies using mouse models in which the core components of the NF-kappaB pathway, namely the IkappaB kinase subunits (IKKalpha, IKKbeta and NEMO), the IkappaB proteins (IkappaBalpha, IkappaBbeta, IkappaBvarepsilon and Bcl-3) and the five NF-kappaB transcription factors (NF-kappaB1, NF-kappaB2, c-Rel, RelA and RelB), have been genetically manipulated using transgenic and knockout technology.
核因子-κB（NF-κB）信号通路在调节包括细胞分裂、细胞存活、分化、免疫和炎症等生理过程的转录反应中发挥着关键作用。在此，我们概述了使用小鼠模型的研究，其中NF-κB通路的核心组分，即IκB激酶亚基（IKKα、IKKβ和NEMO）、IκB蛋白（IκBα、IκBβ、IκBε和Bcl-3）以及五个NF-κB转录因子（NF-κB1、NF-κB2、c-Rel、RelA和RelB），已通过转基因和敲除技术进行了基因操作。
