TBK1 在癌症免疫生物学中的新兴作用。
Emerging roles of TBK1 in cancer immunobiology.
机构信息
Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
出版信息
Trends Cancer. 2024 Jun;10(6):531-540. doi: 10.1016/j.trecan.2024.02.007. Epub 2024 Mar 21.
Abstract
TANK-binding kinase 1 (TBK1) is a versatile serine/threonine protein kinase with established roles in innate immunity, metabolism, autophagy, cell death, and inflammation. While best known for its role in regulating innate immunity, TBK1 has emerged as a cancer cell-intrinsic immune evasion gene by virtue of its role in modulating cellular responses to inflammatory signals emanating from the immune system. Beyond its effect on cancer cells, TBK1 appears to regulate lymphoid and myeloid cells in the tumor immune microenvironment. In this review, we detail recent advances in our understanding of the tumor-intrinsic and -extrinsic roles and regulation of TBK1 in tumor immunity.
摘要
TANK 结合激酶 1（TBK1）是一种多功能丝氨酸/苏氨酸蛋白激酶，在先天免疫、代谢、自噬、细胞死亡和炎症中具有明确的作用。虽然 TBK1 最为人所知的是其在调节先天免疫中的作用，但它通过调节细胞对免疫系统发出的炎症信号的反应，已成为一种癌细胞内在的免疫逃避基因。除了对癌细胞的影响外，TBK1 似乎还调节肿瘤免疫微环境中的淋巴样细胞和髓样细胞。在这篇综述中，我们详细介绍了我们对 TBK1 在肿瘤免疫中的肿瘤内在和外在作用及其调控的最新理解。
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