Keeling D M, Campbell S J, Mackie I J, Machin S J, Isenberg D A
Department of Haematology, University College and Middlesex School of Medicine, London.
Br J Haematol. 1991 Mar;77(3):354-9. doi: 10.1111/j.1365-2141.1991.tb08583.x.
Patients with systemic lupus erythematosus (SLE) have an increased risk of thrombosis and this is increased in the presence of antiphospholipid antibodies (APA). These APA are also associated with thrombosis in patients who do not have SLE. We compared haemostatic parameters in SLE patients with and without APA, and also compared patients who had APA but not SLE with healthy normal controls. No relationships between the natural anticoagulants, antithrombin III, heparin cofactor II, protein C and protein S, and the presence of APA were found. In the patients with SLE both tissue plasminogen activator antigen and plasminogen activator inhibitor (PAI) were increased, but these changes were not due to APA which had no effect on fibrinolysis in these patients. In the patients with APA who did not have SLE the fibrinolytic response to venous occlusion was reduced due to raised levels of PAI; similar changes have, however, been reported in some patients with idiopathic thrombosis.
系统性红斑狼疮（SLE）患者发生血栓形成的风险增加，而在存在抗磷脂抗体（APA）的情况下，这种风险会进一步升高。这些APA在无SLE的患者中也与血栓形成有关。我们比较了有和没有APA的SLE患者的止血参数，还将有APA但无SLE的患者与健康正常对照进行了比较。未发现天然抗凝剂抗凝血酶III、肝素辅因子II、蛋白C和蛋白S与APA的存在之间存在关联。在SLE患者中，组织纤溶酶原激活物抗原和纤溶酶原激活物抑制剂（PAI）均升高，但这些变化并非由APA引起，APA对这些患者的纤维蛋白溶解没有影响。在无SLE但有APA的患者中，由于PAI水平升高，对静脉闭塞的纤维蛋白溶解反应降低；然而，在一些特发性血栓形成患者中也报告了类似的变化。
