抗细胞因子疫苗与自身免疫性疾病的免疫治疗
Anti-cytokine vaccines and the immunotherapy of autoimmune diseases.
作者信息
Wraith David C
机构信息
Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, Bristol, UK.
出版信息
Eur J Immunol. 2006 Nov;36(11):2844-8. doi: 10.1002/eji.200636760.
Abstract
Three papers in this issue of the European Journal of Immunology describe the use of cytokine vaccines to prevent autoimmune disease in experimental animals. The vaccines are based on interleukin 17 (IL-17), a cytokine that has recently been shown to play a central role in inflammation.
摘要
本期《欧洲免疫学杂志》上的三篇论文描述了使用细胞因子疫苗预防实验动物自身免疫性疾病的情况。这些疫苗基于白细胞介素17（IL-17），这是一种最近被证明在炎症中起核心作用的细胞因子。
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本文引用的文献
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Two types of mouse helper T-cell clone Implications for immune regulation.两种类型的小鼠辅助性T细胞克隆对免疫调节的意义。
Immunol Today. 1987;8(7-8):223-7. doi: 10.1016/0167-5699(87)90171-X.
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Development of an anti-IL-17A auto-vaccine that prevents experimental auto-immune encephalomyelitis.一种预防实验性自身免疫性脑脊髓炎的抗白细胞介素-17A自身疫苗的研发。
Eur J Immunol. 2006 Nov;36(11):2868-74. doi: 10.1002/eji.200636662.
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Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis.针对白细胞介素-17进行疫苗接种可抑制自身免疫性关节炎和脑脊髓炎。
Eur J Immunol. 2006 Nov;36(11):2857-67. doi: 10.1002/eji.200636658.
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Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis.通过主动免疫中和IL-17可抑制IL-23依赖性自身免疫性心肌炎。
Eur J Immunol. 2006 Nov;36(11):2849-56. doi: 10.1002/eji.200636484.
5
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.孤儿核受体RORγt指导促炎性白细胞介素-17+辅助性T细胞的分化程序。
Cell. 2006 Sep 22;126(6):1121-33. doi: 10.1016/j.cell.2006.07.035.
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A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis.白细胞介素（IL）-1在介导自身免疫性脑脊髓炎的产生IL-17的T细胞诱导中起关键作用。
J Exp Med. 2006 Jul 10;203(7):1685-91. doi: 10.1084/jem.20060285. Epub 2006 Jul 3.
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IL-23 promotes tumour incidence and growth.白细胞介素-23促进肿瘤的发生和生长。
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8
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.致病性效应T辅助细胞17（TH17）和调节性T细胞产生的相互发育途径。
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