Widmer M B
Immunex Research and Development Corporation, Seattle, Washington.
Curr Opin Biotechnol. 1991 Dec;2(6):872-6. doi: 10.1016/s0958-1669(05)80124-7.
Multiple lines of evidence implicate cytokines in the pathogenesis of autoimmune and inflammatory diseases. Neutralization of the biological activities of cytokines by interfering with ligand binding to specific cell-surface cytokine receptors thus represents an approach to controlling such diseases. Several agents, including novel, receptor-based antagonists, are being developed and tested in disease models.
多条证据表明细胞因子与自身免疫性疾病和炎症性疾病的发病机制有关。通过干扰配体与特定细胞表面细胞因子受体的结合来中和细胞因子的生物学活性，因此是控制此类疾病的一种方法。包括新型基于受体的拮抗剂在内的几种药物正在疾病模型中进行研发和测试。
