多重耐药结核分枝杆菌，班吉，中非共和国。
Multidrug-resistant Mycobacterium tuberculosis, Bangui, Central African Republic.
作者信息
Nouvel Laurent X, Kassa-Kelembho Eric, Dos Vultos Tiago, Zandanga Germain, Rauzier Jean, Lafoz Carmen, Martin Carlos, Blazquez Jesus, Talarmin Antoine, Gicquel Brigitte
机构信息
Institut Pasteur, Paris, France.
出版信息
Emerg Infect Dis. 2006 Sep;12(9):1454-6. doi: 10.3201/eid1209.060361.
We investigated multidrug-resistant (MDR) Mycobacterium tuberculosis strains in Bangui, Central African Republic. We found 39.6% with the same spoligotype and synonymous single nucleotide polymorphism in the mutT1 gene. However, strains had different rpoB mutations responsible for rifampin resistance. MDR strains in Bangui may emerge preferentially from a single, MDR-prone family.
我们对中非共和国班吉的耐多药结核分枝杆菌菌株进行了调查。我们发现39.6%的菌株具有相同的间隔寡核苷酸分型（spoligotype）以及mutT1基因中的同义单核苷酸多态性。然而，这些菌株具有不同的导致利福平耐药的rpoB基因突变。班吉的耐多药菌株可能优先源自单一的、易于产生耐多药的菌群。
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