Filliol Ingrid, Driscoll Jeffrey R, Van Soolingen Dick, Kreiswirth Barry N, Kremer Kristin, Valétudie Georges, Anh Dang Duc, Barlow Rachael, Banerjee Dilip, Bifani Pablo J, Brudey Karine, Cataldi Angel, Cooksey Robert C, Cousins Debby V, Dale Jeremy W, Dellagostin Odir A, Drobniewski Francis, Engelmann Guido, Ferdinand Séverine, Gascoyne-Binzi Deborah, Gordon Max, Gutierrez M Cristina, Haas Walter H, Heersma Herre, Källenius Gunilla, Kassa-Kelembho Eric, Koivula Tuija, Ly Ho Minh, Makristathis Athanasios, Mammina Caterina, Martin Gerald, Moström Peter, Mokrousov Igor, Narbonne Valérie, Narvskaya Olga, Nastasi Antonino, Niobe-Eyangoh Sara Ngo, Pape Jean W, Rasolofo-Razanamparany Voahangy, Ridell Malin, Rossetti M Lucia, Stauffer Fritz, Suffys Philip N, Takiff Howard, Texier-Maugein Jeanne, Vincent Véronique, De Waard Jacobus H, Sola Christophe, Rastogi Nalin
Unité de la tuberculose et des Mycobactéries, Institut Pasteur, Pointe-á-Pitre, Guadeloupe, French West Indies.
Emerg Infect Dis. 2002 Nov;8(11):1347-9. doi: 10.3201/eid0811.020125.
We present a short summary of recent observations on the global distribution of the major clades of the Mycobacterium tuberculosis complex, the causative agent of tuberculosis. This global distribution was defined by data-mining of an international spoligotyping database, SpolDB3. This database contains 11708 patterns from as many clinical isolates originating from more than 90 countries. The 11708 spoligotypes were clustered into 813 shared types. A total of 1300 orphan patterns (clinical isolates showing a unique spoligotype) were also detected.
我们简要总结了近期关于结核分枝杆菌复合群主要进化枝全球分布情况的观察结果，结核分枝杆菌复合群是结核病的病原体。这种全球分布是通过对国际间隔寡核苷酸分型数据库SpolDB3进行数据挖掘来确定的。该数据库包含来自90多个国家的11708株临床分离株的分型模式。这11708个寡核苷酸分型被聚类为813个共享型。还检测到总共1300个孤儿模式（临床分离株显示独特的寡核苷酸分型）。
