Janssen S, Huson M A M, Bélard S, Stolp S, Kapata N, Bates M, van Vugt M, Grobusch M P
Department of Infectious Diseases, Division of Internal Medicine, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands.
Infection. 2014 Apr;42(2):281-94. doi: 10.1007/s15010-013-0568-y. Epub 2013 Dec 6.
Reliable and comprehensive data on the HIV/AIDS and TB co-pandemics from Central Africa remain scarce. This systematic review provides a comprehensive overview on current and past research activities in the region and provides a basis for future research work to close knowledge gaps.
The scientific literature was searched for publications meeting the following search terms: "tuberculosis" or "HIV" or "acquired immunodeficiency syndrome", combined with "Central Africa", or the names of individual countries within the region. Original studies, reviews and case series were included, and a selection of relevant articles was made.
Most research in the field of HIV and TB has been conducted in Cameroon, where the epidemics have been described fairly well. The Democratic Republic of Congo ranked second on the amount of publications, despite the civil wars over the past several decades. Very little has been published on HIV and TB in the other countries, possibly due to the poor infrastructure of health care systems, lack of scientific capacity building or shortage of laboratory equipment.
Despite the relatively high burden of HIV and TB in the Central African region, the amount of research activities on these topics is limited. A better understanding of the co-epidemics in this region is urgently needed. The occurrence of opportunistic infections, treatment complications and drug resistance in TB and HIV need to be better described; the failure of public health systems needs to be understood, and research infrastructure needs to be developed. Only then will it be possible to turn the tide against the HIV and TB epidemics in this region.
来自中非的关于艾滋病毒/艾滋病和结核病合并大流行的可靠且全面的数据仍然匮乏。本系统综述全面概述了该地区当前和过去的研究活动，并为未来填补知识空白的研究工作提供了基础。
检索科学文献以查找符合以下检索词的出版物：“结核病”或“艾滋病毒”或“获得性免疫缺陷综合征”，并与“中非”或该地区内各个国家的名称相结合。纳入原始研究、综述和病例系列，并挑选了相关文章。
艾滋病毒和结核病领域的大多数研究是在喀麦隆进行的，该国对这两种流行病的情况描述得较为详尽。尽管过去几十年经历了内战，但刚果民主共和国在出版物数量上排名第二。其他国家关于艾滋病毒和结核病的出版物极少，这可能是由于医疗保健系统基础设施薄弱、缺乏科学能力建设或实验室设备短缺所致。
尽管中非地区艾滋病毒和结核病的负担相对较高，但关于这些主题的研究活动数量有限。迫切需要更好地了解该地区的合并流行病情况。需要更详尽地描述结核病和艾滋病毒中机会性感染、治疗并发症及耐药性的发生情况；需要了解公共卫生系统的失灵情况，并发展研究基础设施。只有这样，才有可能扭转该地区艾滋病毒和结核病的流行趋势。
