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[脂双层中黑寡妇蜘蛛毒素通道的选择性]

[Selectivity of latrotoxin channel in lipid bilayers].

作者信息

Krasil'nikov O V, Sabirov R Z, Ternovskiĭ V I, Merzliak P G, Tashmukhamedov B A

出版信息

Biofizika. 1990 Sep-Oct;35(5):801-4.

PMID:1707314
Abstract

It is established that high initial K-TEA and Ca2(+)-K+ selectivity of channel form by latrotoxin in lipid bilayers (LT-channel) may be reduced by lowering the pH value and by increasing electrolytes concentration of solution. It is suggested that LT-channel is water-filled pore cation selectivity which is defined by the electrostatic potential on the mouth of the channel, which is induced by the ionogenic group of toxin.

摘要

已经确定,在脂质双层中由拉毒素形成的通道(LT通道)的高初始K-TEA和Ca2(+)-K+选择性可通过降低pH值和增加溶液中电解质浓度来降低。有人提出,LT通道是充满水的孔阳离子选择性通道,其由通道口处的静电势决定,该静电势由毒素的离子ogenic基团诱导产生。

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