Kolomytkin O V, Kasymov S K, Salikhov S I
1 Institute of Biological Physics, Academy of Sciences USSR, Moscow.
Gen Physiol Biophys. 1988 Apr;7(2):157-63.
Asymmetric ion channels are formed in a bimolecular lipid membrane by beta-latrotoxin (LT) introduced to one (cis) side of the membrane. LT-specific antibodies added to the opposite (trans) side of the membrane block the current through the LT channels when a negative potential is applied to the cis side, no blockade is observed at positive potentials. LT-specific antibodies do not block the channel current when added to the cis compartment after removal of LT. LT-unspecific immunoglobulins have no influence on LT channel conductance.
