Hexapeptides HLDF-6 and PEDF-6 restore memory in rats after chronic intracerebroventricular treatment with beta-amyloid peptide Abeta(25-35).

作者信息

Storozheva Z I, Proshin A T, Zhokhov S S, Sherstnev V V, Rodionov I L, Lipkin V M, Kostanyan I A

机构信息

Laboratory of Neurochemistry, P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences.

出版信息

Bull Exp Biol Med. 2006 Mar;141(3):319-22. doi: 10.1007/s10517-006-0160-x.

Effects of homologous peptides HLDF-6 and PEDF-6 on behavior of animals with experimental Alzheimer's disease induced by chronic intracerebroventricular administration of beta-amyloid peptide Abeta(25-35) were studied in the zoosocial recognition test and Morris water maze. Peptides HLDF-6 and PEDF-6 possessed neuroprotective activity and counteracted the toxic effect of Abeta(25-35). Peptides HLDF-6 and PEDF-6 mainly improved long-term memory and working memory, respectively.