Cheng Zhiliang, D'Ambruoso Gemma D, Aspinwall Craig A
Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA.
Langmuir. 2006 Nov 7;22(23):9507-11. doi: 10.1021/la061542i.
Chemically stabilized, porous phospholipid nanoshells (PPNs) were prepared via copolymerization of reactive monomers with unilamellar bis-Sorbyl phosphatidylcholine vesicles. The resulting PPN vesicular assemblies possess a highly porous membrane structure that allows passage of small molecules, which can react with encapsulated proteins and reporters. The unique combination of membrane stability and porosity will prove useful for preparing nanometer-sized sensor, container, and reactor platforms stable in harsh chemical and biological environments.
通过将反应性单体与单层双山梨醇磷脂酰胆碱囊泡共聚，制备了化学稳定的多孔磷脂纳米壳（PPN）。所得的PPN囊泡组装体具有高度多孔的膜结构，允许小分子通过，这些小分子可以与封装的蛋白质和报告分子发生反应。膜稳定性和孔隙率的独特组合将证明对制备在恶劣化学和生物环境中稳定的纳米级传感器、容器和反应器平台有用。
