Dong Yao-Da, Larson Ian, Hanley Tracey, Boyd Ben J
Department of Pharmaceutics, Victoria College of Pharmacy, Monash University, Parkville, Victoria 3052, Australia.
Langmuir. 2006 Nov 7;22(23):9512-8. doi: 10.1021/la061706v.
Phytantriol (3,7,11,15-tetramethylhexadecane-1,2,3-triol, PHYT) is a cosmetic ingredient that exhibits similar lyotropic phase behavior to monoolein (GMO), forming bicontinuous cubic liquid crystalline structures (Q(II)) at low temperatures and reversed hexagonal phase (H(II)) at higher temperatures in excess water. Despite these similarities, phytantriol has received little attention in the scientific community. In this study, the thermal phase behavior of the binary PHYT-water and ternary PHYT-vitamin E acetate (VitEA)-water systems have been studied and compared with the behavior of the dispersed cubosomes and hexosomes formed with the aid of a stabilizer (Pluronic F127). The phase behavior and nanostructure were studied using crossed polarized light microscopy (CPLM), differential scanning calorimetry (DSC), and small-angle X-ray scattering (SAXS) techniques. The presence of lipophilic VitEA in the PHYT-water system suppressed the temperature of the Q(II)-to-H(II)-to-L2 transitions, indicating that lipophilic compounds, in relatively small amounts, may have a significant impact on the phase behavior. Increasing the F127 concentration in the phytantriol-based cubosome system did not induce the Q(II)(Pn3m) to Q(II)(Im3m) transition known for the GMO-water system. This indicates a different mode of interaction between F127 and the lipid domains of phytantriol-water systems. Taken together, these results indicate that phytantriol may not only provide an alternative lipid for preparation of liquid crystalline systems in excess water but may also provide access to properties not available when using GMO.
植烷三醇（3,7,11,15 - 四甲基十六烷 - 1,2,3 - 三醇，PHYT）是一种化妆品成分，其呈现出与单油酸甘油酯（GMO）相似的溶致相行为，在低温下形成双连续立方液晶结构（Q(II)），在过量水中温度较高时形成反相六角相（H(II)）。尽管有这些相似之处，但植烷三醇在科学界却很少受到关注。在本研究中，对二元PHYT - 水体系和三元PHYT - 维生素E醋酸酯（VitEA） - 水体系的热相行为进行了研究，并与借助稳定剂（普朗尼克F127）形成的分散立方液晶和六角液晶的行为进行了比较。使用偏光显微镜（CPLM）、差示扫描量热法（DSC）和小角X射线散射（SAXS）技术研究了相行为和纳米结构。PHYT - 水体系中亲脂性VitEA的存在抑制了Q(II)到H(II)再到L2转变的温度，这表明相对少量的亲脂性化合物可能对相行为有显著影响。在基于植烷三醇的立方液晶体系中增加F127的浓度并未引发GMO - 水体系中已知的Q(II)(Pn3m)到Q(II)(Im3m)转变。这表明F127与植烷三醇 - 水体系的脂质域之间存在不同的相互作用模式。综上所述，这些结果表明植烷三醇不仅可为在过量水中制备液晶体系提供一种替代脂质，还可能带来使用GMO时无法获得的特性。
