Miroslavova N S, Mitchell J E, Tebbutt J, Busby S J W
School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK.
Biochem Soc Trans. 2006 Dec;34(Pt 6):1075-8. doi: 10.1042/BST0341075.
Genetics and biochemistry have been exploited to investigate transcription activation by the Escherichia coli CRP (cAMP receptor protein) factor at promoters with a DNA site for CRP near position -41 and the effects of a second upstream-bound CRP molecule. We show that the upstream-bound CRP contributes to transcription activation by improving the recruitment of RNA polymerase.
遗传学和生物化学已被用于研究大肠杆菌CRP（cAMP受体蛋白）因子在启动子处的转录激活，该启动子在-41位附近有一个CRP的DNA位点，以及第二个上游结合的CRP分子的作用。我们表明，上游结合的CRP通过改善RNA聚合酶的募集来促进转录激活。
