Wright M C
Liver Research Faculty Group, School of Clinical and Laboratory Sciences, Level 2 William Leech Building, Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Biochem Soc Trans. 2006 Dec;34(Pt 6):1119-23. doi: 10.1042/BST0341119.
The PXR (pregnane X receptor) is a nuclear receptor transcription factor that is activated by a range of endobiotics and xenobiotics. The activated PXR modulates the transcription of genes in hepatocytes (the main functional cell of the liver) associated with endobiotic and xenobiotic uptake, metabolism and excretion. However, activation of the PXR also inhibits a deleterious response of the liver to chronic damage--that of fibrosis. The antifibrogenic mode of action is mediated through changes in the expression of genes in hepatic stellate cells and liver macrophages (Kupffers). These results suggest an additional function for the PXR.
孕烷X受体（PXR）是一种核受体转录因子，可被一系列内源性物质和外源性物质激活。被激活的PXR可调节肝细胞（肝脏的主要功能细胞）中与内源性物质和外源性物质摄取、代谢及排泄相关基因的转录。然而，PXR的激活还可抑制肝脏对慢性损伤的有害反应——纤维化反应。抗纤维化作用模式是通过肝星状细胞和肝巨噬细胞（库普弗细胞）中基因表达的变化介导的。这些结果表明PXR具有额外的功能。
