儿童特应性皮炎：离婚的另一个有害后果。

Atopic eczema in children: another harmful sequel of divorce.

作者信息

Bockelbrink A, Heinrich J, Schäfer I, Zutavern A, Borte M, Herbarth O, Schaaf B, von Berg A, Schäfer T

机构信息

Department of Medical Statistics and Epidemiology, Technical University Munich, Munich, Germany.

出版信息

Allergy. 2006 Dec;61(12):1397-402. doi: 10.1111/j.1398-9995.2006.01186.x.

DOI:10.1111/j.1398-9995.2006.01186.x

PMID:17073868

Abstract

BACKGROUND

Different lifestyle factors seem to be associated with the risk for atopic diseases and some studies suggest that stress increases the risk of allergic sensitization, asthma and atopic eczema. Only few studies have investigated the association of early stressful life events and atopic eczema (AE) in children.

SUBJECTS AND METHODS

Parents of participants of the ongoing LISA birth cohort study were asked to give information on life events, such as severe disease or death of a family member, unemployment, or divorce of the parents. Lifetime prevalence of AE and incidence after the assessment period for life events were compared.

RESULTS

Prevalence of AE until the age of 4 years was 21.4%. Reported life events within the first 2 years were: severe disease (17.5%) or death (8.4%) of a family member, divorce/separation (3.4%), and unemployment (2.7%). Divorce/separation was associated with a significantly [odds ratio (OR) 3.59, 95% confidence interval (CI) 1.69-7.66] increased and disease with a significantly (OR 0.29, 95% CI 0.13-0.68) decreased incidence of AE for the subsequent 2 years of life. No effect was seen for unemployment.

CONCLUSIONS

Divorce/separation of the parents and severe disease of a family member influence the risk of developing AE.

摘要

背景

不同的生活方式因素似乎与特应性疾病的风险相关，一些研究表明压力会增加过敏致敏、哮喘和特应性皮炎的风险。仅有少数研究调查了儿童早期应激性生活事件与特应性皮炎（AE）之间的关联。

对象与方法

正在进行的LISA出生队列研究的参与者的父母被要求提供有关生活事件的信息，如家庭成员的重病或死亡、失业或父母离婚。比较了AE的终生患病率和生活事件评估期后的发病率。

结果

4岁前AE的患病率为21.4%。头两年报告的生活事件有：家庭成员重病（17.5%）或死亡（8.4%）、离婚/分居（3.4%）以及失业（2.7%）。离婚/分居与随后两年AE的发病率显著升高[比值比（OR）3.59，95%置信区间（CI）1.69 - 7.66]相关，而家庭成员重病则与AE的发病率显著降低（OR 0.29，95% CI 0.13 - 0.68）相关。未观察到失业有影响。