波萨达斯球孢子菌在体外及感染过程中会产生黑色素。
Coccidioides posadasii produces melanin in vitro and during infection.
作者信息
Nosanchuk Joshua D, Yu Jieh-Juen, Hung Chiung-Yu, Casadevall Arturo, Cole Garry T
机构信息
Department of Medicine (Division of Infectious Diseases), Albert Einstein College of Medicine, Bronx, NY 10461, USA.
出版信息
Fungal Genet Biol. 2007 Jun;44(6):517-20. doi: 10.1016/j.fgb.2006.09.006. Epub 2006 Oct 30.
Using techniques developed to study melanization in other fungi, we demonstrate that Coccidioides posadasii arthroconidia, spherules, and endospores produce melanin or melanin-like compounds in vitro and tissue forms synthesize pigment in vivo. Since melanin is an important virulence factor in other pathogenic fungi, it may affect the pathogenesis of coccidioidomycosis.
利用开发用于研究其他真菌黑色素化的技术，我们证明了波萨达斯球孢子菌的关节孢子、球形体和内生孢子在体外产生黑色素或黑色素样化合物，并且组织形式在体内合成色素。由于黑色素是其他致病真菌中的一种重要毒力因子，它可能会影响球孢子菌病的发病机制。
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