Liu Sichen, Youngchim Sirida, Zamith-Miranda Daniel, Nosanchuk Joshua D
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
J Fungi (Basel). 2021 Mar 31;7(4):264. doi: 10.3390/jof7040264.
Melanins are ubiquitous complex polymers that are commonly known in humans to cause pigmentation of our skin. Melanins are also present in bacteria, fungi, and helminths. In this review, we will describe the diverse interactions of fungal melanin with the mammalian immune system. We will particularly focus on and also discuss other major melanotic pathogenic fungi. Melanin interacts with the immune system through diverse pathways, reducing the effectiveness of phagocytic cells, binding effector molecules and antifungals, and modifying complement and antibody responses.
黑色素是普遍存在的复杂聚合物，在人类中通常被认为会导致皮肤色素沉着。黑色素也存在于细菌、真菌和蠕虫中。在本综述中，我们将描述真菌黑色素与哺乳动物免疫系统的多种相互作用。我们将特别关注并讨论其他主要的黑色素致病真菌。黑色素通过多种途径与免疫系统相互作用，降低吞噬细胞的有效性，结合效应分子和抗真菌药物，并改变补体和抗体反应。
