Foster M W, Royal C D M, Sharp R R
Department of Anthropology, University of Oklahoma, 455 W Lindsey, Rm 505C, Norman, OK 73019, USA.
J Med Ethics. 2006 Nov;32(11):635-8. doi: 10.1136/jme.2005.013532.
Among bioethicists and members of the public, genetics is often regarded as unique in its ethical challenges. As medical researchers and clinicians increasingly combine genetic information with a range of non-genetic information in the study and clinical management of patients with common diseases, the unique ethical challenges attributed to genetics must be re-examined. A process of genetic routinisation that will have implications for research and clinical ethics, as well as for public conceptions of genetic information, is constituted by the emergence of new forms of genetic medicine, in which genetic information is interpreted in a multifactorial frame of reference. Although the integration of genetics in medical research and treatment may be a helpful corrective to the mistaken assumptions of genetic essentialism or determinism, the routinisation of genetics may have unintended consequences for the protection of genetic information, perceptions of non-genetic information and the loss of genetic research as a laboratory for exploring issues in research and clinical ethics. Consequently, new ethical challenges are presented by the increasing routinisation of genetic information in both biomedical and public spheres.
在生物伦理学家和公众看来,遗传学在伦理挑战方面往往被视为独一无二。随着医学研究人员和临床医生在常见疾病患者的研究和临床管理中越来越多地将基因信息与一系列非基因信息相结合,归因于遗传学的独特伦理挑战必须重新审视。新形式的基因医学的出现构成了一个基因常规化的过程,这将对研究和临床伦理以及公众对基因信息的观念产生影响,在这种新形式的基因医学中,基因信息是在多因素参照系中进行解读的。尽管遗传学融入医学研究和治疗可能有助于纠正基因本质主义或决定论的错误假设,但遗传学的常规化可能会对基因信息的保护、对非基因信息的认知以及作为探索研究和临床伦理问题的实验室的基因研究的丧失产生意想不到的后果。因此,生物医学和公共领域中基因信息日益常规化带来了新的伦理挑战。