McEniery Carmel M, Cockcroft John R
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Adv Cardiol. 2007;44:160-172. doi: 10.1159/000096728.
Coronary heart disease is a major cause of death and morbidity. Due to the increased longevity of most developed societies, there is an increasing overlap between arteriosclerosis associated with normal vascular ageing and atherosclerosis associated with cardiovascular risk factors. There is therefore a need for improvements, both in the early identification of individuals at risk, and in cardiovascular risk stratification. Arterial stiffness is an important determinant of cardiovascular risk and can now be measured simply and noninvasively in large populations. This review will therefore focus on the current evidence as to the predictive value of arterial stiffness in relation to coronary events and also on the possible pathophysiological mechanisms linking arterial stiffness and atherosclerosis.
冠心病是死亡和发病的主要原因。由于大多数发达社会人群寿命延长，与正常血管老化相关的动脉硬化和与心血管危险因素相关的动脉粥样硬化之间的重叠日益增加。因此，在高危个体的早期识别以及心血管风险分层方面都需要改进。动脉僵硬度是心血管风险的重要决定因素，现在可以在大量人群中进行简单且无创的测量。因此，本综述将聚焦于目前关于动脉僵硬度对冠心病事件预测价值的证据，以及动脉僵硬度与动脉粥样硬化之间可能的病理生理机制。
