Kumova Deniz, Aktas Zeynep, Eyiol Azmi, Hasanreisoglu Murat, Cemri Mustafa
Department of Ophthalmology, Sultangazi Haseki Education Research Hospital, Istanbul, Turkey.
Department of Ophthalmology, Gazi University Medical Faculty, Ankara, Turkey.
J Curr Glaucoma Pract. 2021 May-Aug;15(2):86-90. doi: 10.5005/jp-journals-10078-1300.
To evaluate the relationship between aortic distensibility (AD) and aortic stiffness B index (ASBI) with retinal nerve fiber layer (RNFL) thickness measured with HD-OCT in peripheral arterial disease (PAD) patients.
Twenty-six PAD patients and 22 age-matched healthy control were enrolled. Subjects with PAD were classified into two groups. Patients with diabetes (DM) or hypertension (HT) comprised group I ( = 18) and without DM or HT comprised group II ( = 8). Color Doppler imaging was performed on all patients and PAD was diagnosed by using the ankle-brachial index (ABI). Retinal nerve fiber layer thickness values between control and PAD patients and correlations between RNFL thickness and aortic stiffness parameters (AD and ASBI) were evaluated.
The inferior-nasal and inferior-temporal quadrant were the thickest in healthy subjects and the PAD group. Retinal nerve fiber layer thickness significantly decreased in superior-nasal, temporal, inferior-nasal quadrants in group I than healthy subjects ( < 0.001, = 0.005, < 0.001). Temporal and inferior-nasal quadrant thicknesses were statistically significantly thinner in group II than controls ( = 0.02, < 0.001). The nasal RNFL quadrant was significantly thinner in group I than group II ( = 0.014). The correlation between RNFL thickness and aortic elasticity parameters in each group was not found to be significant.
Isolated PAD without DM or HT may lead to localized RNFL loss in temporal and inferior-nasal quadrants. Aortic elasticity parameters did not seem to be correlated with RNFL thickness in PAD.
Kumova D, Aktas Z, Eyiol A, Relationship between Retinal Nerve Fiber Layer Thickness and Aortic Distensibility in Peripheral Arterial Disease Patients. J Curr Glaucoma Pract 2021;15(2):86-90.
评估外周动脉疾病（PAD）患者中，主动脉扩张性（AD）和主动脉僵硬度B指数（ASBI）与通过高清光学相干断层扫描（HD-OCT）测量的视网膜神经纤维层（RNFL）厚度之间的关系。
纳入26例PAD患者和22例年龄匹配的健康对照者。患有PAD的受试者被分为两组。患有糖尿病（DM）或高血压（HT）的患者组成第一组（n = 18），无DM或HT的患者组成第二组（n = 8）。对所有患者进行彩色多普勒成像，并使用踝臂指数（ABI）诊断PAD。评估对照组和PAD患者之间的视网膜神经纤维层厚度值，以及RNFL厚度与主动脉僵硬度参数（AD和ASBI）之间的相关性。
在健康受试者和PAD组中，鼻下象限和颞下象限最厚。与健康受试者相比，第一组的鼻上、颞侧、鼻下象限的视网膜神经纤维层厚度显著降低（P < 0.001，P = 0.005，P < 0.001）。与对照组相比，第二组的颞侧和鼻下象限厚度在统计学上显著变薄（P = 0.02，P < 0.001）。第一组的鼻侧RNFL象限比第二组显著更薄（P = 0.014）。未发现每组中RNFL厚度与主动脉弹性参数之间存在显著相关性。
无DM或HT的孤立性PAD可能导致颞侧和鼻下象限局部RNFL丢失。在PAD中，主动脉弹性参数似乎与RNFL厚度无关。
Kumova D, Aktas Z, Eyiol A, 外周动脉疾病患者视网膜神经纤维层厚度与主动脉扩张性之间的关系。《当代青光眼实践杂志》2021；15（2）：86 - 90。
