Abramson Jerome L, Vaccarino Viola
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Ga. , USA.
Adv Cardiol. 2007;44:223-233. doi: 10.1159/000096733.
Recent studies have reported positive associations between pulse pressure (PP) and markers of inflammation. These studies are intriguing because they suggest that elevations in PP could induce an inflammatory state and thereby increase the risk of inflammation- related diseases such as atherosclerotic cardiovascular disease. In the present chapter, we review potential mechanisms by which an elevated PP could increase inflammation. We also review human-based studies that have investigated the association between PP and inflammatory biomarkers such as C-reactive protein. The majority of studies support a positive association between PP and inflammatory markers. However, it remains unclear whether the association is truly causal and whether it has relevance in terms of predicting cardiovascular diseases.
最近的研究报道了脉压（PP）与炎症标志物之间存在正相关。这些研究很有趣，因为它们表明脉压升高可能诱发炎症状态，从而增加诸如动脉粥样硬化性心血管疾病等炎症相关疾病的风险。在本章中，我们综述了脉压升高可能增加炎症的潜在机制。我们还综述了以人体为研究对象、探究脉压与炎症生物标志物（如C反应蛋白）之间关联的研究。大多数研究支持脉压与炎症标志物之间存在正相关。然而，这种关联是否真的具有因果关系以及它在预测心血管疾病方面是否具有相关性仍不明确。
