Department of Translational Medical Sciences, Federico II University, Naples, Italy.
Unit of Cardiology and Intensive Care, "Umberto I" Hospital, Nocera Inferiore, Salerno, Italy.
Panminerva Med. 2021 Jun;63(2):122-132. doi: 10.23736/S0031-0808.21.04266-X. Epub 2021 Feb 10.
Atherosclerosis is a dynamic process driven by all cardiovascular risk factors that can be briefly divided into an early and a late phase. Inflammation is one of the fundamental substrates that initiates the atherosclerotic process in the early stages and promotes and maintains it in the final stages. In the last decades, clinical and experimental data have shown that inflammation is supported by mediators that respond to physical activity. The present review aimed at investigating the effect of physical exercise on inflammatory mediators, both the positive ones that have a proinflammatory effect (interleukin 6, c-reactive protein and tumor necrosis factor α, interferon γ, high-mobility group box-1), and the negative ones which have an anti-inflammatory effect (interleukin 10). Pooled data support the evidence that physical exercise can directly modulate the activity of inflammatory cytokines slowing down or preventing the formation of the atherosclerotic stage.
动脉粥样硬化是一种由所有心血管危险因素驱动的动态过程，可以简要地分为早期和晚期两个阶段。炎症是启动早期动脉粥样硬化过程并促进和维持晚期过程的基本底物之一。在过去的几十年中，临床和实验数据表明，炎症是由对身体活动有反应的介质支持的。本综述旨在研究身体活动对炎症介质的影响，包括具有促炎作用的阳性介质（白细胞介素 6、C 反应蛋白和肿瘤坏死因子 α、干扰素 γ、高迁移率族蛋白 1）和具有抗炎作用的阴性介质（白细胞介素 10）。汇总数据支持这样的证据，即身体活动可以直接调节炎症细胞因子的活性，从而减缓或防止动脉粥样硬化阶段的形成。
