Gijare P S, Rao K V, Bhide S V
Carcinogenesis Division, Tata Memorial Centre, Parel, Bombay, India.
Nutr Cancer. 1990;14(3-4):253-9. doi: 10.1080/01635589009514101.
The hamster cheek pouch (HCP) serves as an excellent model system not only for the studies on initiation and promotion but also for the modulation of experimental oral carcinogenesis. In our studies, HCPs treated with 7,12-dimethylbenz[a]anthracene (DMBA) showed both cheek pouch and stomach papillomas. Utilizing this model system, we tested and compared the modulatory effects of snuff, retinoic acid, and beta-carotene on the incidence of tumors and the keratin expression pattern. HCPs treated with snuff, either alone or in combination with DMBA, resulted in stomach papillomas. HCPs treated with snuff showed no cheek pouch tumors, and those treated with snuff and DMBA showed only 10-15% tumor incidence. Both beta-carotene and retinoic acid showed a total inhibition of DMBA-induced carcinogenesis in the HCP as well as in the stomach. The keratin expression pattern showed alterations depending on the experimental conditions.
仓鼠颊囊（HCP）不仅是研究起始和促进过程的优秀模型系统，也是研究实验性口腔癌发生调节的优秀模型系统。在我们的研究中，用7,12-二甲基苯并[a]蒽（DMBA）处理的HCP出现了颊囊和胃乳头状瘤。利用这个模型系统，我们测试并比较了鼻烟、视黄酸和β-胡萝卜素对肿瘤发生率和角蛋白表达模式的调节作用。单独用鼻烟或与DMBA联合处理的HCP会导致胃乳头状瘤。用鼻烟处理的HCP未出现颊囊肿瘤，用鼻烟和DMBA处理的HCP肿瘤发生率仅为10%-15%。β-胡萝卜素和视黄酸均显示出对HCP以及胃中DMBA诱导的致癌作用的完全抑制。角蛋白表达模式根据实验条件而发生改变。
