Ertan S, Ulu M O, Hanimoglu H, Tanriverdi T, Kafadar A M, Acar Z U, Kiziltan G
Department of Neurology, Cerrahpasa Faculty of Medicine, Istanbul University, PK 4 Cerrahpasa 34301, Istanbul, Turkey.
Singapore Med J. 2006 Nov;47(11):981-3.
This report presents a 30-year-old man who developed subacute phenytoin-induced cerebellar ataxia and parkinsonism that resolved after discontinuation of the phenytoin treatment. Phenytoin was started for seizure prophylaxis in another health institution where he was referred for bilateral intracerebral orbitofrontal haemorrhage due to a head trauma. To our knowledge, there has been only one other case report describing phenytoin-induced parkinsonism, which was also reversible. The issue of the development of parkinsonism due to the phenytoin toxicity in the case of bilateral orbitofrontal lesion is addressed.
本报告介绍了一名30岁男性，他出现了亚急性苯妥英钠诱发的小脑共济失调和帕金森综合征，在停用苯妥英钠治疗后症状缓解。该患者因头部外伤导致双侧脑内眶额叶出血，被转诊至另一家医疗机构，在那里开始使用苯妥英钠预防癫痫发作。据我们所知，仅有另一例病例报告描述了苯妥英钠诱发的帕金森综合征，该病例也是可逆的。本文探讨了在双侧眶额叶病变情况下，因苯妥英钠毒性导致帕金森综合征的问题。
