Chen J-M, Guo Y-J, Wu K-Y, Guo J-F, Wang M, Dong J, Zhang Y, Li Z, Shu Y-L
Chinese National Influenza Center, Institute of Viral Disease Control, China CDC, Beijing, China.
Arch Virol. 2007 Feb;152(2):415-22. doi: 10.1007/s00705-006-0852-6. Epub 2006 Nov 2.
The Victoria lineage represented by B/Victoria/2/87 is one of the two major distinctive haemagglutinin (HA) lineages of influenza B virus, and its recent re-emergence has aroused great concerns. However, it remains unknown when, where, and how this HA lineage emerged in the world. In this study, the HA1 domain of the HA gene of fourteen influenza B viruses isolated in China in 1972-1984 was sequenced. The sequences were phylogenetically analyzed with the HA1 sequences of 41 other important influenza B isolates. The results unveiled some earlier footprints of the Victoria lineage in China, and the epidemic history of the Victoria lineage could be traced back from the year 1985 to 1975. Moreover, phylogenetic analysis, the history of China, and the epidemiology of influenza B virus indicated that the Victoria lineage possibly emerged in China in the 1970s through gradual evolution from a minor lineage.
以B/维多利亚/2/87为代表的维多利亚谱系是乙型流感病毒两个主要不同血凝素（HA）谱系之一，其近期再度出现引起了极大关注。然而，该HA谱系在世界上何时、何地以及如何出现仍不清楚。在本研究中，对1972 - 1984年在中国分离的14株乙型流感病毒的HA基因的HA1结构域进行了测序。将这些序列与其他41株重要乙型流感病毒分离株的HA1序列进行了系统发育分析。结果揭示了维多利亚谱系在中国的一些早期踪迹，且该谱系的流行历史可追溯至1985年至1975年。此外，系统发育分析、中国历史以及乙型流感病毒的流行病学表明，维多利亚谱系可能于20世纪70年代在中国通过从一个小谱系逐渐进化而出现。
