Albeda F W, van der Meer J, Vellenga E
Department of Pathology, State University of Groningen, The Netherlands.
Am J Clin Pathol. 1991 Apr;95(4):564-6. doi: 10.1093/ajcp/95.4.564.
One year after splenectomy, a patient with myelofibrosis developed spontaneously large hematomas that were not due to coagulation abnormalities or functionally defective platelets. At autopsy, the liver, muscle, and skin showed extramedullary hematopoiesis associated with capillary proliferation and extravasation of blood. These findings indicate that neovascularization can be an additional cause of bleeding in myeloproliferative disorders and might be induced by neoplastic hematopoietic cells.
脾切除术后一年，一名骨髓纤维化患者自发出现大量血肿，这并非由凝血异常或功能缺陷的血小板所致。尸检时，肝脏、肌肉和皮肤显示有髓外造血，并伴有毛细血管增生和血液外渗。这些发现表明，新生血管形成可能是骨髓增殖性疾病出血的另一个原因，且可能由肿瘤性造血细胞诱导产生。
