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春川地区绝经后女性骨质疏松症的患病率及相关因素:翰林衰老研究(HAS)

[Prevalence and associated factors of osteoporosis among postmenopausal women in Chuncheon: Hallym Aging Study (HAS)].

作者信息

Jang Soong-Nang, Choi Young-Ho, Choi Moon-Gi, Kang Sung-Hyun, Jeong Jin-Young, Choi Yong-Jun, Kim Dong-Hyun

机构信息

Institute of Health and Environment, Seoul National University.

出版信息

J Prev Med Public Health. 2006 Sep;39(5):389-96.

Abstract

OBJECTIVES

A community-based, cross-sectional survey was conducted to determine theprevalence of osteoporosis and to evaluate the effects of body composition, health behaviors and reproductive history on bone density in postmenopausal women.

METHODS

The study subjects were 362 postmenopausal women, aged 45 years old or over, who were invited to the hospital. Information on their socio-demographic characteristics and the potential risk factors such as their past medical history, smoking, alcohol intake, exercise, diet and menstrual/reproductive histories were collected by trained interviewers. Weight, height, the body mass index (kg/m2), and body composition variables were measured. Bone mineral density of the lumbar spine was measured by dual energy X-ray absorptiometry (DXA).

RESULTS

The prevalence of osteoporosis was 30.6% in the 45-64 years old women, 52.5% in the elderly women aged 65-74, and 68.7% in the women aged 75 years or over. After adjustment for the effect of potential covariates, those women in the highest 25% (4th quartile) of the lean body mass are less likely to have osteoporosis (aOR=0.31, 95% CI=0.12-0.76), compared with the lowest quartile group. More parity also had significantly detrimental effects on osteoporosis.

CONCLUSIONS

These findings suggest that the prevalence of osteoporosis in postmenopausal women increased with age from 46.3% of those aged 45-64 to 68.7% for those aged 75 and over. Lean body mass and parity appeared significant contributor to bone mineral density in postmenopausal women in this population.

摘要

目的

开展一项基于社区的横断面调查,以确定骨质疏松症的患病率,并评估身体成分、健康行为和生殖史对绝经后女性骨密度的影响。

方法

研究对象为362名年龄在45岁及以上的绝经后女性,她们被邀请到医院。由经过培训的访谈员收集她们的社会人口学特征信息以及潜在风险因素,如既往病史、吸烟、饮酒、运动、饮食和月经/生殖史。测量体重、身高、体重指数(kg/m2)和身体成分变量。采用双能X线吸收法(DXA)测量腰椎骨密度。

结果

45 - 64岁女性骨质疏松症患病率为30.6%,65 - 74岁老年女性为52.5%,75岁及以上女性为68.7%。在对潜在协变量的影响进行调整后,与最低四分位数组相比,瘦体重处于最高25%(第4四分位数)的女性患骨质疏松症的可能性较小(调整后比值比=0.31,95%置信区间=0.12 - 0.76)。更多的孕产次数对骨质疏松症也有显著的不利影响。

结论

这些发现表明,绝经后女性骨质疏松症的患病率随年龄增加,从45 - 64岁人群的46.3%增至75岁及以上人群的68.7%。在该人群中,瘦体重和孕产次数似乎是绝经后女性骨密度的重要影响因素。

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