Krasniqi Ermira, Koni Mynyr, Tschan Harald, Krasniqi Blerim, Kabashi Antigona, Boshnjaku Arben
Medical University of Tirana, Faculty of Medical Technical Sciences, Tirana, Albania; Medical Sciences College Rezonanca, Prishtinë, Kosovo.
Medical University of Tirana, Faculty of Medical Technical Sciences, Tirana, Albania; University of Tirana, Faculty of Natural Sciences, Tirana, Albania.
Med Arch. 2016 Oct;70(5):359-363. doi: 10.5455/medarh.2016.70.359-363. Epub 2016 Oct 25.
This observational, cross-sectional study investigates the impact of medication usage, physical activity (PA) and nutritional status on musculoskeletal health (MSH) in males and females aged 40-65 in the population of a post conflict, developing country.
Bone Mineral Density (BMD), T-score and Z-score at distal forearm regions (measured by DEXA scan), together with isometric hand grip strength (dynamometer) were evaluated in a total of 162 subjects (53 Males, average age 55.15±7.12 and 109 Females, 54.27±5.1). Additionally, bio-anthropometric assessments, medication usage, PA level and nutritional status were assessed.
Significant differences (p<0.05) were found in total subjects Body Mass Index (BMI), PA, BMD, T-score and Hand grip between genders. 42% of total participants met the diagnostic criteria of, out of which 6.8% with T-score below -2, while no cases of Osteoporosis was recorded. N05B Anxiolytics and A02B Drugs for peptic ulcer and gastro-oesophageal reflux disease medication groups consumption turned to have no significant differences (p>0.05) in BMD, T-score, and hand grip in total population, except for A02B where p<0.05 were found in Hand grip, as well as between female consumers and no consumers in all variables. Meanwhile, in total subjects consuming H02AB Glucocorticoids p<0.05 were observed in BMD and T-score, but not on hand grip.
This study shows a low risk for MSH problems amongst the studied population in Kosova, while the consumption of H02AB medication group in both genders and A02B in females only for extended periods might effect MSH, therefore appropriate benefit/risk assessment should be made before prescribing these medications, notwithstanding age, gender, PA or nutritional status.
这项观察性横断面研究调查了在一个冲突后发展中国家的40 - 65岁人群中，药物使用、身体活动（PA）和营养状况对男性和女性肌肉骨骼健康（MSH）的影响。
总共对162名受试者（53名男性，平均年龄55.15±7.12岁；109名女性，54.27±5.1岁）进行了评估，测量了远端前臂区域的骨矿物质密度（BMD）、T值和Z值（通过双能X线吸收法扫描测量），以及等长握力（握力计）。此外，还进行了生物人体测量评估、药物使用情况、PA水平和营养状况评估。
在所有受试者的体重指数（BMI）、PA、BMD、T值和握力方面，发现性别之间存在显著差异（p<0.05）。42%的总参与者符合诊断标准，其中6.8%的T值低于 -2，而未记录到骨质疏松病例。N05B类抗焦虑药和A02B类用于消化性溃疡和胃食管反流病的药物组的消费情况在总体人群的BMD、T值和握力方面没有显著差异（p>0.05），但A02B类药物在握力方面p<0.05，在所有变量中女性消费者和非消费者之间也存在差异。同时，在所有服用H02AB类糖皮质激素的受试者中，观察到BMD和T值方面p<0.05，但在握力方面没有差异。
本研究表明科索沃研究人群中MSH问题风险较低，而男女长期服用H02AB类药物组以及仅女性长期服用A02B类药物可能会影响MSH，因此在开这些药物之前，无论年龄、性别、PA或营养状况如何，都应进行适当的获益/风险评估。
