依那普利和舒林酸对皮肤对P物质和神经激肽A反应的影响。
The effects of enalapril and sulindac on the dermal response to substance P and neurokinin A.
作者信息
Ferner R E, Kamali F, Rawlins M D
机构信息
Wolfson Unit of Clinical Pharmacology, University of Newcastle upon Tyne.
出版信息
Br J Clin Pharmacol. 1991 Jan;31(1):114-6. doi: 10.1111/j.1365-2125.1991.tb03869.x.
Abstract
The effects of pretreatment with enalapril, and sulindac, on the weal response to intradermal injections of substance P and neurokinin A were assessed in a randomised, double-blind, placebo-controlled study. Weal responses to both substance P and neurokinin A depended significantly on dose. Neither enalapril nor sulindac, nor the combination of these agents influenced the responses to either tachykinin. These results do not suggest any role for substance P or neurokinin A in the clinical effects of angiotensin converting enzyme inhibitors.
摘要
在一项随机、双盲、安慰剂对照研究中，评估了依那普利和舒林酸预处理对皮内注射P物质和神经激肽A所致风团反应的影响。对P物质和神经激肽A的风团反应均显著依赖于剂量。依那普利、舒林酸或二者联合使用均不影响对任何一种速激肽的反应。这些结果并不提示P物质或神经激肽A在血管紧张素转换酶抑制剂的临床效应中起任何作用。
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本文引用的文献
1
The captopril-induced eruption. A possible mechanism: cutaneous kinin potentiation.
Arch Dermatol. 1980 Aug;116(8):902-5.
2
Structure-activity relationships for some substance P-related peptides that cause wheal and flare reactions in human skin.一些在人体皮肤中引起风团和潮红反应的P物质相关肽的构效关系。
J Physiol. 1983 Feb;335:449-65. doi: 10.1113/jphysiol.1983.sp014543.
3
Characterization of a dipeptide hydrolase (kininase II: angiotensin I converting enzyme).一种二肽水解酶（激肽酶II：血管紧张素I转换酶）的特性描述
J Pharmacol Exp Ther. 1971 Apr;177(1):291-300.
4
Potentiation of inflammatory reactions in guinea-pig skin by an angiotensin converting enzyme inhibitor (MK 422).血管紧张素转换酶抑制剂（MK 422）对豚鼠皮肤炎症反应的增强作用。
Eur J Pharmacol. 1987 Mar 31;135(3):383-7. doi: 10.1016/0014-2999(87)90688-1.
5
Effects of intradermal bradykinin after inhibition of angiotensin converting enzyme.血管紧张素转换酶抑制后皮内注射缓激肽的效应
Br Med J (Clin Res Ed). 1987 May 2;294(6580):1119-20. doi: 10.1136/bmj.294.6580.1119.
6
Angio-oedema and urticaria associated with angiotensin converting enzyme inhibitors.血管性水肿和荨麻疹与血管紧张素转换酶抑制剂相关。
Br Med J (Clin Res Ed). 1987 Jan 10;294(6564):91-2. doi: 10.1136/bmj.294.6564.91.
7
Effect of enalapril on the skin response to bradykinin in man.依那普利对人体皮肤对缓激肽反应的影响。
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Sensory neuropeptide effects in human skin.感觉神经肽对人体皮肤的影响。
Br J Pharmacol. 1987 Dec;92(4):781-8. doi: 10.1111/j.1476-5381.1987.tb11381.x.
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Lancet. 1987 Apr 11;1(8537):872. doi: 10.1016/s0140-6736(87)91663-1.
10
The effects of intradermal bradykinin are potentiated by angiotensin converting enzyme inhibitors in hypertensive patients.在高血压患者中，血管紧张素转换酶抑制剂可增强皮内缓激肽的作用。
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