依那普利对人体皮肤对缓激肽反应的影响。
Effect of enalapril on the skin response to bradykinin in man.
作者信息
Fuller R W, Warren J B, McCusker M, Dollery C T
出版信息
Br J Clin Pharmacol. 1987 Jan;23(1):88-90. doi: 10.1111/j.1365-2125.1987.tb03014.x.
Abstract
We tested the effect of oral enalapril on intradermal bradykinin to determine if kininase II inhibition occurs with therapeutic doses in vivo. Six normal male volunteers took either 5 mg enalapril orally or placebo on 2 days. Three hours later bradykinin was injected into the skin of the back in doses increasing from 10(-11) to 10(-9) M. Enalapril increased the bradykinin-induced wheal. Inhibition of kininase II may cause accumulation of endogenous bradykinin. This could be an important mechanism in the occasionally reported side effect of angioedema with the angiotensin converting enzyme (ACE) inhibiting group of drugs.
摘要
我们测试了口服依那普利对皮内缓激肽的作用，以确定在体内治疗剂量下是否会发生激肽酶II抑制。六名正常男性志愿者在两天内分别口服5毫克依那普利或安慰剂。三小时后，将缓激肽以从10（-11）到10（-9）M递增的剂量注射到背部皮肤中。依那普利增加了缓激肽诱导的风团。激肽酶II的抑制可能导致内源性缓激肽的积累。这可能是血管紧张素转换酶（ACE）抑制类药物偶尔报告的血管性水肿副作用的重要机制。
相似文献
1
Effect of enalapril on the skin response to bradykinin in man.依那普利对人体皮肤对缓激肽反应的影响。
Br J Clin Pharmacol. 1987 Jan;23(1):88-90. doi: 10.1111/j.1365-2125.1987.tb03014.x.
2
The effect of sulindac on dermal responses to bradykinin in normal subjects given an angiotensin converting enzyme inhibitor.舒林酸对服用血管紧张素转换酶抑制剂的正常受试者皮肤对缓激肽反应的影响。
Br J Clin Pharmacol. 1990 Mar;29(3):363-5. doi: 10.1111/j.1365-2125.1990.tb03649.x.
3
A comparison of the effects of captopril and enalapril on skin responses to intradermal bradykinin and skin blood flow in the human forearm.卡托普利和依那普利对人前臂皮肤对皮内注射缓激肽的反应及皮肤血流影响的比较。
Br J Clin Pharmacol. 1993 Jan;35(1):8-13. doi: 10.1111/j.1365-2125.1993.tb05663.x.
4
The effect of indomethacin and enalapril on the cutaneous response to bradykinin.吲哚美辛和依那普利对皮肤对缓激肽反应的影响。
Br J Clin Pharmacol. 1989 Jun;27(6):870-2. doi: 10.1111/j.1365-2125.1989.tb03452.x.
5
The effects of intradermal bradykinin are potentiated by angiotensin converting enzyme inhibitors in hypertensive patients.在高血压患者中，血管紧张素转换酶抑制剂可增强皮内缓激肽的作用。
Br J Clin Pharmacol. 1989 Mar;27(3):337-42. doi: 10.1111/j.1365-2125.1989.tb05374.x.
6
Absence of potentiation of the skin response to intradermal bradykinin by a long-acting angiotensin converting enzyme inhibitor, trandolapril, at conventional antihypertensive dosage in human volunteers: a double-blind, randomized, cross-over, placebo-controlled trial.长效血管紧张素转换酶抑制剂群多普利在常规降压剂量下对人类志愿者皮内注射缓激肽的皮肤反应无增强作用：一项双盲、随机、交叉、安慰剂对照试验。
Postgrad Med J. 1992 Sep;68(803):742-5. doi: 10.1136/pgmj.68.803.742.
7
Effects of intradermal bradykinin after inhibition of angiotensin converting enzyme.血管紧张素转换酶抑制后皮内注射缓激肽的效应
Br Med J (Clin Res Ed). 1987 May 2;294(6580):1119-20. doi: 10.1136/bmj.294.6580.1119.
8
New aspects on inflammatory reactions and cough following inhibiton of angiotensin converting enzyme.
Acta Physiol Scand Suppl. 1988;573:1-60.
9
Bradykinin contributes to the systemic hemodynamic effects of chronic angiotensin-converting enzyme inhibition in patients with heart failure.缓激肽在心力衰竭患者中对慢性血管紧张素转换酶抑制的全身血流动力学效应起作用。
Arterioscler Thromb Vasc Biol. 2004 Jun;24(6):1043-8. doi: 10.1161/01.ATV.0000129331.21092.1d. Epub 2004 Apr 22.
10
Effect of kininase II inhibitors on bradykinin-stimulated bovine sperm motility.
Theriogenology. 1998 Sep;50(4):651-7. doi: 10.1016/s0093-691x(98)00169-1.
引用本文的文献
1
ACE inhibitor-induced cough and bronchospasm. Incidence, mechanisms and management.
Drug Saf. 1996 Jul;15(1):72-8. doi: 10.2165/00002018-199615010-00006.
2
A comparison of the effects of captopril and enalapril on skin responses to intradermal bradykinin and skin blood flow in the human forearm.卡托普利和依那普利对人前臂皮肤对皮内注射缓激肽的反应及皮肤血流影响的比较。
Br J Clin Pharmacol. 1993 Jan;35(1):8-13. doi: 10.1111/j.1365-2125.1993.tb05663.x.
3
Severe angioedema and respiratory distress associated with lisinopril use.与使用赖诺普利相关的严重血管性水肿和呼吸窘迫。
West J Med. 1993 Apr;158(4):412-7.
4
Proceedings of the British Pharmacological Society, Clinical Pharmacology Section. Ireland, 6-8 July, 1988. Abstracts.英国药理学会临床药理学分会会议记录。爱尔兰，1988年7月6日至8日。摘要。
Br J Clin Pharmacol. 1988 Nov;26(5):615P-678P.
5
Cough and angiotensin converting enzyme inhibition.咳嗽与血管紧张素转换酶抑制
Br Med J (Clin Res Ed). 1988 May 7;296(6632):1279. doi: 10.1136/bmj.296.6632.1279.
6
Renin inhibitors as possible antihypertensive agents.
Klin Wochenschr. 1988 Sep 15;66(18):906-13. doi: 10.1007/BF01728953.
7
The importance of bradykinin and histamine in the skin response to antigen.缓激肽和组胺在皮肤对抗抗原反应中的重要性。
Br J Clin Pharmacol. 1988 Dec;26(6):803-5. doi: 10.1111/j.1365-2125.1988.tb05324.x.
8
Bronchial hyperreactivity in patients who cough after receiving angiotensin converting enzyme inhibitors.接受血管紧张素转换酶抑制剂后咳嗽患者的支气管高反应性。
Br Med J (Clin Res Ed). 1988 Jan 9;296(6615):86-8. doi: 10.1136/bmj.296.6615.86.
9
Angiotensin-converting enzyme inhibitors and their influence on inflammation, bronchial reactivity and cough. A research review.血管紧张素转换酶抑制剂及其对炎症、支气管反应性和咳嗽的影响。一项研究综述。
Med Toxicol Adverse Drug Exp. 1989 Sep-Oct;4(5):369-80. doi: 10.1007/BF03259918.
10
Involvement of the kallikrein-kinin system in the antihypertensive effect of the angiotensin converting enzyme inhibitors.激肽释放酶-激肽系统在血管紧张素转换酶抑制剂降压作用中的参与。
Br J Clin Pharmacol. 1989;27 Suppl 2(Suppl 2):175S-180S. doi: 10.1111/j.1365-2125.1989.tb03479.x.
本文引用的文献
1
Some statistical methods useful in circulation research.一些在循环研究中有用的统计方法。
Circ Res. 1980 Jul;47(1):1-9. doi: 10.1161/01.res.47.1.1.
2
Pharmacology of bradykinin and related kinins.缓激肽及相关激肽的药理学
Pharmacol Rev. 1980 Mar;32(1):1-46.
3
Evidence in man of synergistic interaction between putative mediators of acute inflammation and asthma.人体中急性炎症与哮喘假定介质之间协同相互作用的证据。
Lancet. 1982 Apr 24;1(8278):935-7. doi: 10.1016/s0140-6736(82)91935-3.
4
Mechanisms of blood vessel permeability derangement under the influence of permeability factors (histamine, serotonin, kinins) and inflammatory agents.通透性因子（组胺、5-羟色胺、激肽）和炎症介质影响下血管通透性紊乱的机制。
Biochem Pharmacol. 1972 Jan;21(1):89-95. doi: 10.1016/0006-2952(72)90253-5.
5
Kinins in human disease.人类疾病中的激肽
Annu Rev Med. 1971;22:63-84. doi: 10.1146/annurev.me.22.020171.000431.
6
The effects of captopril (SQ 14,225) on bradykinin-induced bronchoconstriction in the anesthetized guinea pig.卡托普利（SQ 14,225）对麻醉豚鼠中缓激肽诱导的支气管收缩的影响。
Eur J Pharmacol. 1979 Aug 15;57(4):287-94. doi: 10.1016/0014-2999(79)90491-6.
Zotero 插件