通过非酶酰化催化剂对二氢吲哚进行动力学拆分
Kinetic resolutions of indolines by a nonenzymatic acylation catalyst.
作者信息
Arp Forrest O, Fu Gregory C
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
出版信息
J Am Chem Soc. 2006 Nov 8;128(44):14264-5. doi: 10.1021/ja0657859.
Abstract
The first method for the kinetic resolution of indolines through catalytic N-acylation is described. To improve the selectivity factor, new planar-chiral PPY-derived catalysts were synthesized, wherein the chiral environment was systematically modified. This work provides a rare example of a nonenzyme-based acylation catalyst for the kinetic resolution of amines.
摘要
描述了通过催化N-酰化对吲哚啉进行动力学拆分的第一种方法。为了提高选择性因子，合成了新型平面手性PPY衍生催化剂，其中对手性环境进行了系统修饰。这项工作为胺的动力学拆分提供了一个罕见的基于非酶酰化催化剂的例子。
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