钯催化下吲哚啉与α-酮酸的脱羧酰化反应：一种合成7-取代吲哚的简便策略。
Decarboxylative acylation of indolines with α-keto acids under palladium catalysis: a facile strategy for the synthesis of 7-substituted indoles.
作者信息
Kim Minyoung, Mishra Neeraj Kumar, Park Jihye, Han Sangil, Shin Youngmi, Sharma Satyasheel, Lee Youngil, Lee Eui-Kyung, Kwak Jong Hwan, Kim In Su
机构信息
School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
出版信息
Chem Commun (Camb). 2014 Nov 25;50(91):14249-52. doi: 10.1039/c4cc06929c.
PMID:25284736
Abstract
Palladium-catalyzed decarboxylative acylation of highly substituted indolines with α-keto acids via C-H bond activation is described. This protocol provides efficient access to C7-carbonylated indoles known to have diverse biological profiles.
摘要
描述了通过C-H键活化，钯催化的高取代二氢吲哚与α-酮酸的脱羧酰化反应。该方法提供了一种有效合成已知具有多种生物学特性的C7-羰基化吲哚的途径。
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