18F单光子发射计算机断层扫描（SPECT）与正电子发射断层扫描（PET）在心肌成像中的比较：一项逼真的胸部-心脏体模研究。

Comparison of 18F SPECT with PET in myocardial imaging: a realistic thorax-cardiac phantom study.

作者信息

Knešaurek Karin, Machac Josef

机构信息

Division of Nuclear Medicine, The Mount Sinai Medical Center, New York, USA.

出版信息

BMC Nucl Med. 2006 Oct 31;6:5. doi: 10.1186/1471-2385-6-5.

DOI:10.1186/1471-2385-6-5

PMID:17076890

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1634842/

Abstract

BACKGROUND

Positron emission tomography (PET) imaging with fluorine-18 (18F) Fluorodeoxyglucose (FDG) and flow tracer such as Rubidium-82 (82Rb) is an established method for evaluating an ischemic but viable myocardium. However, the high cost of PET imaging restricts its wider clinical use. Therefore, less expensive 18F FDG single photon emission computed tomography (SPECT) imaging has been considered as an alternative to 18F FDG PET imaging. The purpose of the work is to compare SPECT with PET in myocardial perfusion/viability imaging.

METHODS

A nonuniform RH-2 thorax-heart phantom was used in the SPECT and PET acquisitions. Three inserts, 3 cm, 2 cm and 1 cm in diameter, were placed in the left ventricular (LV) wall to simulate infarcts. The phantom acquisition was performed sequentially with 7.4 MBq of 18F and 22.2 MBq of Technetium-99m (99mTc) in the SPECT study and with 7.4 MBq of 18F and 370 MBq of 82Rb in the PET study. SPECT and PET data were processed using standard reconstruction software provided by vendors. Circumferential profiles of the short-axis slices, the contrast and viability of the inserts were used to evaluate the SPECT and PET images.

RESULTS

The contrast for 3 cm, 2 cm and 1 cm inserts were for 18F PET data, 1.0 +/- 0.01, 0.67 +/- 0.02 and 0.25 +/- 0.01, respectively. For 82Rb PET data, the corresponding contrast values were 0.61 +/- 0.02, 0.37 +/- 0.02 and 0.19 +/- 0.01, respectively. For 18F SPECT the contrast values were, 0.31 +/- 0.03 and 0.20 +/- 0.05 for 3 cm and 2 cm inserts, respectively. For 99mTc SPECT the contrast values were, 0.63 +/- 0.04 and 0.24 +/- 0.05 for 3 cm and 2 cm inserts respectively. In SPECT, the 1 cm insert was not detectable. In the SPECT study, all three inserts were falsely diagnosed as "viable", while in the PET study, only the 1 cm insert was diagnosed falsely "viable".

CONCLUSION

For smaller defects the 99mTc/18F SPECT imaging cannot entirely replace the more expensive 82Rb/18F PET for myocardial perfusion/viability imaging, due to poorer image spatial resolution and poorer defect contrast.

摘要

背景

正电子发射断层扫描（PET）成像结合氟-18（18F）氟脱氧葡萄糖（FDG）和血流示踪剂如铷-82（82Rb）是评估缺血但存活心肌的既定方法。然而，PET成像的高成本限制了其更广泛的临床应用。因此，成本较低的18F FDG单光子发射计算机断层扫描（SPECT）成像被视为18F FDG PET成像的替代方法。这项工作的目的是比较SPECT和PET在心肌灌注/存活成像方面的差异。

方法

在SPECT和PET采集过程中使用了一个不均匀的RH-2胸部-心脏模型。在左心室（LV）壁中放置三个直径分别为3厘米、2厘米和1厘米的插入物，以模拟梗死。在SPECT研究中，模型采集依次使用7.4 MBq的18F和22.2 MBq的锝-99m（99mTc），在PET研究中依次使用7.4 MBq的18F和370 MBq的82Rb。SPECT和PET数据使用供应商提供的标准重建软件进行处理。短轴切片的圆周轮廓、插入物的对比度和存活情况用于评估SPECT和PET图像。

结果

对于直径为3厘米、2厘米和1厘米的插入物，18F PET数据的对比度分别为1.0±0.01、0.67±0.02和0.25±0.01。对于82Rb PET数据，相应的对比度值分别为0.61±0.02、0.37±0.02和0.19±0.01。对于18F SPECT，直径为3厘米和2厘米的插入物的对比度值分别为0.31±0.03和0.20±0.05。对于99mTc SPECT，直径为3厘米和2厘米的插入物的对比度值分别为0.63±0.04和0.24±0.05。在SPECT中，1厘米的插入物无法检测到。在SPECT研究中，所有三个插入物均被误诊为“存活”，而在PET研究中，只有1厘米的插入物被误诊为“存活”。