Shin Taehoon, Hu Houchun H, Pohost Gerald M, Nayak Krishna S
Ming Hsieh Department of Electrical Engineering, University of Southern California, Los Angeles, California, USA.
J Cardiovasc Magn Reson. 2008 Dec 11;10(1):57. doi: 10.1186/1532-429X-10-57.
In patients with ischemic heart disease, accurate assessment of the extent of myocardial perfusion deficit may be important in predicting prognosis of clinical cardiac outcomes. The aim of this study was to compare the ability of three dimensional (3D) and of two dimensional (2D) multi-slice myocardial perfusion imaging (MPI) using cardiovascular magnetic resonance (CMR) in determining the size of defects, and to demonstrate the feasibility of 3D MPI in healthy volunteers at 3 Tesla.
A heart phantom was used to compare the accuracy of 3D and 2D multi-slice MPI in estimating the volume fraction of seven rubber insets which simulated transmural myocardial perfusion defects. Three sets of cross-sectional planes were acquired for 2D multi-slice imaging, where each set was shifted along the partition encoding direction by +/- 10 mm. 3D first-pass contrast-enhanced (0.1 mmol/kg Gd-DTPA) MPI was performed in three volunteers with sensitivity encoding for six-fold acceleration. The upslope of the myocardial time-intensity-curve and peak SNR/CNR values were calculated.
Mean/standard deviation of errors in estimating the volume fraction across the seven defects were -0.44/1.49%, 2.23/2.97%, and 2.59/3.18% in 3D, 2D 4-slice, and 2D 3-slice imaging, respectively. 3D MPI performed in healthy volunteers produced excellent quality images with whole left ventricular (LV) coverage. Peak SNR/CNR was 57.6 +/- 22.0/37.5 +/- 19.7 over all segments in the first eight slices.
3D performed better than 2D multi-slice MPI in estimating the size of perfusion defects in phantoms. Highly accelerated 3D MPI at 3T was feasible in volunteers, allowing whole LV coverage with excellent image quality and high SNR/CNR.
在缺血性心脏病患者中，准确评估心肌灌注缺损的范围对于预测临床心脏结局的预后可能至关重要。本研究的目的是比较使用心血管磁共振（CMR）的三维（3D）和二维（2D）多层心肌灌注成像（MPI）在确定缺损大小方面的能力，并证明3D MPI在3特斯拉健康志愿者中的可行性。
使用心脏模型比较3D和2D多层MPI在估计七个模拟透壁心肌灌注缺损的橡胶嵌入物的体积分数方面的准确性。获取了三组用于2D多层成像的横断面，每组在分区编码方向上沿±10毫米移动。对三名志愿者进行了3D首过对比增强（0.1 mmol/kg钆喷酸葡胺）MPI，并采用灵敏度编码进行六倍加速。计算了心肌时间-强度曲线的上升斜率和峰值信噪比/对比噪声比值。
在估计七个缺损的体积分数时，3D、2D 4层和2D 3层成像的误差均值/标准差分别为-0.44/1.49%、2.23/2.97%和2.59/3.18%。在健康志愿者中进行的3D MPI产生了覆盖整个左心室（LV）的高质量图像。在前八个层面的所有节段中，峰值信噪比/对比噪声比为57.6±22.0/37.5±19.7。
在估计模型中灌注缺损的大小时，3D比2D多层MPI表现更好。3T下高度加速的3D MPI在志愿者中是可行的，能够实现整个LV覆盖，具有优异的图像质量和高信噪比/对比噪声比。
