Asbell Penny A
Mount Sinai School of Medicine, New York, NY 10029, USA.
Curr Med Res Opin. 2006 Nov;22(11):2149-57. doi: 10.1185/030079906X132640.
Dry eye syndrome is a highly prevalent, yet largely under diagnosed, condition that can substantially affect quality of life. Left untreated, dry eye is associated with chronic eye pain and increased risk of ocular surface disease. Current demographic changes and lifestyle factors indicate that the dry eye syndrome patient population will increase significantly, ensuring that general practitioners and ophthalmic clinicians alike will experience more patients presenting with dry eye symptoms. Greater public and practitioner awareness of emerging research, technologies, and therapies is crucial to ensuring appropriate interventions to meet specific patient needs and result in clinically favorable outcomes.
In August 2005, a team of ocular surface experts convened for a 1-day roundtable session to discuss the latest information on diagnosing and treating dry eye syndrome and real-world issues in artificial tear therapy, including preservative use.
The discussion centered on the mild to moderate dry eye patient and critical features of the ideal artificial tear, which are preservative-free formulation, protection from microbial contamination, cost-effective, non-blurring, and easy to use. Products that match this profile have the advantage of being able to benefit the myriad of patients who comprise the dry eye syndrome population. Ocular surface health should always remain a top priority. Preferred Practice Pattern Dry Eye Syndrome Medical Treatment guidelines should be modified to recommend the use of preservative-free formula artificial tear products for all levels of dry eye conditions in consideration of the medical benefit they offer to dry eye syndrome sufferers.
The growing prevalence of dry eye syndrome demands increased attention. Further research, enhanced diagnostic tests, increased use of preservative-free artificial tear formulations as first-line therapy, greater patient-practitioner interaction, and patient education are warranted.
干眼综合征是一种高度普遍但很大程度上未被诊断出来的疾病,会严重影响生活质量。若不治疗,干眼会导致慢性眼痛并增加眼表疾病的风险。当前的人口结构变化和生活方式因素表明,干眼综合征患者群体将显著增加,这确保了全科医生和眼科临床医生都会接诊到更多有干眼症状的患者。提高公众和从业者对新兴研究、技术及疗法的认识对于确保采取适当干预措施以满足特定患者需求并取得临床良好效果至关重要。
2005年8月,一组眼表专家召开了为期一天的圆桌会议,讨论干眼综合征诊断与治疗的最新信息以及人工泪液治疗中的实际问题,包括防腐剂的使用。
讨论集中在轻度至中度干眼患者以及理想人工泪液的关键特性上,即无防腐剂配方、防止微生物污染、性价比高、不产生模糊、易于使用。符合这一特点的产品能够使构成干眼综合征群体的众多患者受益。眼表健康应始终是首要关注点。应修改《干眼综合征医疗首选实践模式指南》,建议针对所有程度的干眼状况使用无防腐剂配方的人工泪液产品,因为考虑到它们为干眼综合征患者带来的医疗益处。
干眼综合征患病率的不断上升需要更多关注。有必要进行进一步研究、改进诊断测试、增加无防腐剂人工泪液配方作为一线治疗方法的使用、加强医患互动以及开展患者教育。