Ribeiro Marina Viegas Moura Rezende, Barbosa Fabiano Timbó, Ribeiro Luiz Eduardo Feliciano, Sousa-Rodrigues Célio Fernando de, Ribeiro Eurica Adélia Nogueira
Departamento de Oftalmologia, Centro Universitário Tiradentes, Maceió, AL, Brazil.
Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, AL, Brazil.
Arq Bras Oftalmol. 2019 Sep 9;82(5):436-445. doi: 10.5935/0004-2749.20190097.
This systematic review aimed to assess the effectiveness of using preservative-free artificial tears versus preserved lubricants for the treatment of dry eyes in Universidade Federal de Alagoas (PROSPERO 2018 CRD42018089933). Online databases were searched (LILACS, EMBASE, MEDLINE, and CENTRAL) from inception to April 2018; references from included papers were also searched. The following keywords were used: lubricants OR artificial tears OR artificial tears, lubricants AND dry eye OR dry eye syndrome OR syndromes, dry eye OR dry eyes. Among the 2028 electronic search results, 29 full papers were retrieved and four were considered relevant. The number of participants from these studies ranged from 15 to 76. Meta-analysis was possible for the following outcomes: score of symptoms according to the Ocular Surface Disease Index - Allergan (OSDI), tear secretion rate using the Schirmer test, tear evaporation rate using the tear film breakup time test, burning, foreign body sensation, and photophobia. No statistically significant difference was observed between the two groups, and no side effects were attributed to the interventions. Evidence proving that preservative-free artificial tears are more effective than preserved artificial tears is lacking.
本系统评价旨在评估在阿拉戈斯联邦大学（PROSPERO 2018 CRD42018089933）中，使用不含防腐剂的人工泪液与含防腐剂的润滑剂治疗干眼症的有效性。检索了从数据库建立至2018年4月的在线数据库（LILACS、EMBASE、MEDLINE和CENTRAL）；还检索了纳入论文的参考文献。使用了以下关键词：润滑剂或人工泪液或人工泪液、润滑剂与干眼症或干眼综合征或干眼综合征、干眼或干眼症。在2028条电子检索结果中，检索到29篇全文，其中4篇被认为相关。这些研究的参与者人数从15人到76人不等。对于以下结果可以进行荟萃分析：根据眼表疾病指数-爱尔康（OSDI）的症状评分、使用泪液分泌试验的泪液分泌率、使用泪膜破裂时间试验的泪液蒸发率、烧灼感、异物感和畏光。两组之间未观察到统计学上的显著差异，且干预措施未出现副作用。缺乏证据证明不含防腐剂的人工泪液比含防腐剂的人工泪液更有效。
